Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous infusion

Peter P.C. Tan; Ming Hwang Shyr; Chen Hsein Yang; Terry B.J. Kuo; Wynn H.T. Pan; Samuel H.H. Chan

doi:10.1016/0304-3940(93)90414-G

Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous infusion

Peter P.C. Tan, Ming Hwang Shyr, Chen Hsein Yang, Terry B.J. Kuo, Wynn H.T. Pan, Samuel H.H. Chan^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, α, β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	Neuroscience Letters
Volume	160
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(93)90414-G
State	Published - 01 10 1993

Keywords

Anesthesia
Electroencephalogram
Intravenous infusion
Noxious thermal stimulation
Power spectral analysis
Propofol
Rat
Systemic arterial pressure

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10.1016/0304-3940(93)90414-G

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title = "Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous infusion",

abstract = "Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, α, β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography.",

keywords = "Anesthesia, Electroencephalogram, Intravenous infusion, Noxious thermal stimulation, Power spectral analysis, Propofol, Rat, Systemic arterial pressure",

author = "Tan, {Peter P.C.} and Shyr, {Ming Hwang} and Yang, {Chen Hsein} and Kuo, {Terry B.J.} and Pan, {Wynn H.T.} and Chan, {Samuel H.H.}",

year = "1993",

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doi = "10.1016/0304-3940(93)90414-G",

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T1 - Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat

T2 - Intravenous infusion

AU - Tan, Peter P.C.

AU - Shyr, Ming Hwang

AU - Yang, Chen Hsein

AU - Kuo, Terry B.J.

AU - Pan, Wynn H.T.

AU - Chan, Samuel H.H.

PY - 1993/10/1

Y1 - 1993/10/1

N2 - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, α, β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography.

AB - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, α, β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography.

KW - Anesthesia

KW - Electroencephalogram

KW - Intravenous infusion

KW - Noxious thermal stimulation

KW - Power spectral analysis

KW - Propofol

KW - Rat

KW - Systemic arterial pressure

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U2 - 10.1016/0304-3940(93)90414-G

DO - 10.1016/0304-3940(93)90414-G

M3 - 文章

C2 - 8247355

AN - SCOPUS:0027515197

SN - 0304-3940

VL - 160

SP - 205

EP - 208

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous infusion

Abstract

Keywords

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