Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous bolus administration

Ming Hwang Shyr; Chen Hsien Yang; Terry B.J. Kuo; Wynn H.T. Pan; Peter P.C. Tan; Samuel H.H. Chan

doi:10.1016/0304-3940(93)90312-9

Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous bolus administration

Ming Hwang Shyr, Chen Hsien Yang, Terry B.J. Kuo, Wynn H.T. Pan, Peter P.C. Tan, Samuel H.H. Chan^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.

Original language	English
Pages (from-to)	161-164
Number of pages	4
Journal	Neuroscience Letters
Volume	153
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(93)90312-9
State	Published - 30 04 1993
Externally published	Yes

Keywords

Anesthesia
Electroencephalogram
Noxious thermal stimulation
Power spectral analysis
Propofol
Rat
Systemic arterial pressure

Access to Document

10.1016/0304-3940(93)90312-9

Cite this

@article{c43e85e6081c44e2b38d90b437a22c3e,

title = "Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous bolus administration",

abstract = "Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.",

keywords = "Anesthesia, Electroencephalogram, Noxious thermal stimulation, Power spectral analysis, Propofol, Rat, Systemic arterial pressure",

author = "Shyr, {Ming Hwang} and Yang, {Chen Hsien} and Kuo, {Terry B.J.} and Pan, {Wynn H.T.} and Tan, {Peter P.C.} and Chan, {Samuel H.H.}",

year = "1993",

month = apr,

day = "30",

doi = "10.1016/0304-3940(93)90312-9",

language = "英语",

volume = "153",

pages = "161--164",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat

T2 - Intravenous bolus administration

AU - Shyr, Ming Hwang

AU - Yang, Chen Hsien

AU - Kuo, Terry B.J.

AU - Pan, Wynn H.T.

AU - Tan, Peter P.C.

AU - Chan, Samuel H.H.

PY - 1993/4/30

Y1 - 1993/4/30

N2 - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.

AB - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.

KW - Anesthesia

KW - Electroencephalogram

KW - Noxious thermal stimulation

KW - Power spectral analysis

KW - Propofol

KW - Rat

KW - Systemic arterial pressure

UR - http://www.scopus.com/inward/record.url?scp=0027230989&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(93)90312-9

DO - 10.1016/0304-3940(93)90312-9

M3 - 文章

C2 - 8327191

AN - SCOPUS:0027230989

SN - 0304-3940

VL - 153

SP - 161

EP - 164

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous bolus administration

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this