Pre-freeze and post-thaw characteristics on chimerism patterns in double-unit cord blood transplantation

Tang Her Jaing; Pei Kwei Tsay; Tung Liang Lin; Chao Ping Yang; Iou Jih Hung; Yu Chuan Wen

doi:10.1002/pbc.21882

Pre-freeze and post-thaw characteristics on chimerism patterns in double-unit cord blood transplantation

Tang Her Jaing^*, Pei Kwei Tsay, Tung Liang Lin, Chao Ping Yang, Iou Jih Hung, Yu Chuan Wen

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

We analyzed the pre-freeze and post-thaw characteristics on chimerism patterns in 20 cases of double-unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryo- preservation cell dose of 3.7 x 10 ⁷total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 days. By day 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By day 100, one unit predominated in 80% of the patients. Higher pre-freeze TNC and CD34+ cell doses were associated with cord predominance in 67% of patients. Pediatr Blood Cancer

Original language	English
Pages (from-to)	547-550
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	52
Issue number	4
DOIs	https://doi.org/10.1002/pbc.21882
State	Published - 04 2009

Keywords

Cell dose
Double cord blood transplantation
Neutrophil engraftment
Predominant unit

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10.1002/pbc.21882

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abstract = "We analyzed the pre-freeze and post-thaw characteristics on chimerism patterns in 20 cases of double-unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryo- preservation cell dose of 3.7 x 10 7total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 days. By day 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By day 100, one unit predominated in 80% of the patients. Higher pre-freeze TNC and CD34+ cell doses were associated with cord predominance in 67% of patients. Pediatr Blood Cancer",

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AU - Jaing, Tang Her

AU - Tsay, Pei Kwei

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AU - Yang, Chao Ping

AU - Hung, Iou Jih

AU - Wen, Yu Chuan

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KW - Predominant unit

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Pre-freeze and post-thaw characteristics on chimerism patterns in double-unit cord blood transplantation

Abstract

Keywords

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