Pre-freeze and post-thaw characteristics on chimerism patterns in double-unit cord blood transplantation

Tang Her Jaing; Pei Kwei Tsay; Tung Liang Lin; Chao Ping Yang; Iou Jih Hung; Yu Chuan Wen

doi:10.1002/pbc.21882

Pre-freeze and post-thaw characteristics on chimerism patterns in double-unit cord blood transplantation

Tang Her Jaing^*
, Pei Kwei Tsay
, Tung Liang Lin
, Chao Ping Yang
, Iou Jih Hung
, Yu Chuan Wen

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

We analyzed the pre-freeze and post-thaw characteristics on chimerism patterns in 20 cases of double-unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryo- preservation cell dose of 3.7 x 10 ⁷total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 days. By day 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By day 100, one unit predominated in 80% of the patients. Higher pre-freeze TNC and CD34+ cell doses were associated with cord predominance in 67% of patients. Pediatr Blood Cancer

Original language	English
Pages (from-to)	547-550
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	52
Issue number	4
DOIs	https://doi.org/10.1002/pbc.21882
State	Published - 04 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cell dose
Double cord blood transplantation
Neutrophil engraftment
Predominant unit

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10.1002/pbc.21882

Cite this

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title = "Pre-freeze and post-thaw characteristics on chimerism patterns in double-unit cord blood transplantation",

abstract = "We analyzed the pre-freeze and post-thaw characteristics on chimerism patterns in 20 cases of double-unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryo- preservation cell dose of 3.7 x 10 7total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 days. By day 42, neutrophil engraftment was derived from both donors in 63\% of cases and a single donor in 37\% of patients. By day 100, one unit predominated in 80\% of the patients. Higher pre-freeze TNC and CD34+ cell doses were associated with cord predominance in 67\% of patients. Pediatr Blood Cancer",

keywords = "Cell dose, Double cord blood transplantation, Neutrophil engraftment, Predominant unit",

author = "Jaing, \{Tang Her\} and Tsay, \{Pei Kwei\} and Lin, \{Tung Liang\} and Yang, \{Chao Ping\} and Hung, \{Iou Jih\} and Wen, \{Yu Chuan\}",

year = "2009",

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doi = "10.1002/pbc.21882",

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AU - Jaing, Tang Her

AU - Tsay, Pei Kwei

AU - Lin, Tung Liang

AU - Yang, Chao Ping

AU - Hung, Iou Jih

AU - Wen, Yu Chuan

PY - 2009/4

Y1 - 2009/4

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AB - We analyzed the pre-freeze and post-thaw characteristics on chimerism patterns in 20 cases of double-unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryo- preservation cell dose of 3.7 x 10 7total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 days. By day 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By day 100, one unit predominated in 80% of the patients. Higher pre-freeze TNC and CD34+ cell doses were associated with cord predominance in 67% of patients. Pediatr Blood Cancer

KW - Cell dose

KW - Double cord blood transplantation

KW - Neutrophil engraftment

KW - Predominant unit

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M3 - 文章

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Pre-freeze and post-thaw characteristics on chimerism patterns in double-unit cord blood transplantation

Abstract

UN SDGs

Keywords

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