Precursor B-cell acute lymphoblastic leukemia after thymoma and myasthenia gravis: Report of a case and review of the literature

Hung Chang, Tong Jong Chen, Wen Yu Chuang, Tung Liang Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations

Abstract

The association of thymoma, myasthenia gravis (MG) and pure red cell aplasia (PRCA) is well recognized. The association of T-cell lymphoblastic lymphoma and thymoma/MG/PRCA is less distinctive but reported occasionally. We present a 35-year-old female patient who was diagnosed with thymoma and myasthenia gravis. She underwent a thymectomy shortly after the diagnosis. One year later she developed precursor B-cell acute lymphoblastic leukemia (ALL). Complete remission was achieved after induction chemotherapy but the disease relapsed and she expired two years after the diagnosis of ALL despite allogeneic stem cell transplantation. This association has never before been reported and the pathogenesis needs to be clarified. Aberrant thymus function in myasthenia gravis, immunosuppressive therapy and thymectomy are considered to account for the leukemia development in this patient. Free full text available at www.tumorionline.it.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalTumori
Volume97
Issue number1
DOIs
StatePublished - 01 2011

Keywords

  • Acute lymphoblastic leukemia
  • Myasthenia gravis
  • Thymectomy
  • Thymoma

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