Abstract
Background: Most split-night sleep (SNS) studies have enrolled Caucasian patients with moderate-to-severe obstructive sleep apnea-hypopnea syndrome (OSAHS), with different apnea-hypopnea index (AHI) criteria for diagnosis and successful CPAP titration from the standard full-night study (FNS). This study aimed to describe a shortened diagnostic SNS in the Taiwanese population using diagnostic and CPAP therapeutic criteria identical to the standard FNS, and to generate a predictive equation for effective CPAP (Peff) titration. Methods: A total of 418 patients with moderate-to-severe OSAHS were enrolled in this study. The duration of the diagnostic SNS was shortened to approximately 1-2 hours. The diagnostic accuracy and the success rate of CPAP titration in SNS were evaluated and a statistical model for Peff was built. The accuracy of the predictive equation was validated in another 127 patients. Results: Eighty-nine percent of patients with moderate-to-severe OSAHS diagnosed in the preceding FNS yielded the same grade of OSAHS in SNS. These reproducible patients were more severe, with 88% attaining successful CPAP titration in SNS. The predictive Peff=1.98+0.184 BMI+0.01 AHISNS +0.016 DISNS (R2=0.28, p<0.0001) where BMI was the body mass index and DI the desaturation index. The λ predictive Peff - Peff λ was within 2 cm H2O in 84% of the study group and 73% of the validation group. Conclusion: The modified split-night protocol and the predictive equation for CPAP can be useful in Taiwanese patients with moderate-to-severe OSAHS. Our findings may shorten the waiting time for polysomnography.
Original language | English |
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Pages (from-to) | 1585-1592 |
Number of pages | 8 |
Journal | Internal Medicine |
Volume | 47 |
Issue number | 18 |
DOIs | |
State | Published - 2008 |
Externally published | Yes |
Keywords
- Apnea-hypopnea index
- Breathing disturbances
- Polysomnography
- Respiratory disturbance index
- Sleep disorder