Predicting post-hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis

Yi Hsuan Chuang; Hsin You Ou; Marirose Z. Lazo; Chao Long Chen; Meng Hsiang Chen; Ching Chun Weng; Yu Fan Cheng

doi:10.1111/liv.13608

Predicting post-hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis

Yi Hsuan Chuang, Hsin You Ou, Marirose Z. Lazo, Chao Long Chen, Meng Hsiang Chen, Ching Chun Weng, Yu Fan Cheng^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

59 Scopus citations

Abstract

Background & Aims: To assess the efficacy of functional MR image with volumetric, liver function test and indocyanine green clearance (ICG) in identifying the patients who are at risk of post-hepatectomy liver failure (PHLF). Methods: We retrospectively included 115 patients undergoing gadoxetic acid-enhanced MR imaging before hepatectomy at one medical centre from January 2013 to December 2015. Contrast enhancement ratio (CER) between transitional and hepatobiliary phases (3 and 30 minutes post-contrast) was calculated. Total liver volume (TLV) and spleen volume (Sp) were measured. Post-operatively, the histological Ishak fibrosis score was collected. Potential risk factors for liver failure were analysed, and the performance was examined by receiver operating characteristic curve. Results: Post-hepatectomy liver failure (PHLF) occurred in 16 patients (13.9%). TLV/SLV, ADC value, CER_HBP/TP and total liver contrast enhancement ratio (tCER) were associated with PHLF (P <.05). Between PHLF and non-PHLF groups, remnant liver volume (RLV), RLV/SLV, Sp/RLV, remnant liver contrast enhancement ratio (rCER) and Ishak fibrosis score showed statistical difference. rCER showed superiority in diagnostic performance (AUC = 0.78) with the optimal cut-off value of 1.23. Conclusions: Gadoxetic acid-enhanced MR imaging with volumetric is a reliable method for evaluating functional liver volume and determining the risk of PHLF.

Original language	English
Pages (from-to)	868-874
Number of pages	7
Journal	Liver International
Volume	38
Issue number	5
DOIs	https://doi.org/10.1111/liv.13608
State	Published - 05 2018

Bibliographical note

Publisher Copyright:
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

Gd-EOB-DTPA MRI
Post-hepatectomy liver failure
cirrhosis
contrast enhancement ratio

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10.1111/liv.13608

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@article{32f873b0ba7447dc944f9c58145a01b7,

title = "Predicting post-hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis",

abstract = "Background \& Aims: To assess the efficacy of functional MR image with volumetric, liver function test and indocyanine green clearance (ICG) in identifying the patients who are at risk of post-hepatectomy liver failure (PHLF). Methods: We retrospectively included 115 patients undergoing gadoxetic acid-enhanced MR imaging before hepatectomy at one medical centre from January 2013 to December 2015. Contrast enhancement ratio (CER) between transitional and hepatobiliary phases (3 and 30 minutes post-contrast) was calculated. Total liver volume (TLV) and spleen volume (Sp) were measured. Post-operatively, the histological Ishak fibrosis score was collected. Potential risk factors for liver failure were analysed, and the performance was examined by receiver operating characteristic curve. Results: Post-hepatectomy liver failure (PHLF) occurred in 16 patients (13.9\%). TLV/SLV, ADC value, CERHBP/TP and total liver contrast enhancement ratio (tCER) were associated with PHLF (P <.05). Between PHLF and non-PHLF groups, remnant liver volume (RLV), RLV/SLV, Sp/RLV, remnant liver contrast enhancement ratio (rCER) and Ishak fibrosis score showed statistical difference. rCER showed superiority in diagnostic performance (AUC = 0.78) with the optimal cut-off value of 1.23. Conclusions: Gadoxetic acid-enhanced MR imaging with volumetric is a reliable method for evaluating functional liver volume and determining the risk of PHLF.",

keywords = "Gd-EOB-DTPA MRI, Post-hepatectomy liver failure, cirrhosis, contrast enhancement ratio",

author = "Chuang, \{Yi Hsuan\} and Ou, \{Hsin You\} and Lazo, \{Marirose Z.\} and Chen, \{Chao Long\} and Chen, \{Meng Hsiang\} and Weng, \{Ching Chun\} and Cheng, \{Yu Fan\}",

note = "Publisher Copyright: {\textcopyright} 2017 John Wiley \& Sons A/S. Published by John Wiley \& Sons Ltd",

year = "2018",

month = may,

doi = "10.1111/liv.13608",

language = "英语",

volume = "38",

pages = "868--874",

journal = "Liver International",

issn = "1478-3223",

publisher = "Wiley-Blackwell Publishing Ltd",

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TY - JOUR

T1 - Predicting post-hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis

AU - Chuang, Yi Hsuan

AU - Ou, Hsin You

AU - Lazo, Marirose Z.

AU - Chen, Chao Long

AU - Chen, Meng Hsiang

AU - Weng, Ching Chun

AU - Cheng, Yu Fan

PY - 2018/5

Y1 - 2018/5

N2 - Background & Aims: To assess the efficacy of functional MR image with volumetric, liver function test and indocyanine green clearance (ICG) in identifying the patients who are at risk of post-hepatectomy liver failure (PHLF). Methods: We retrospectively included 115 patients undergoing gadoxetic acid-enhanced MR imaging before hepatectomy at one medical centre from January 2013 to December 2015. Contrast enhancement ratio (CER) between transitional and hepatobiliary phases (3 and 30 minutes post-contrast) was calculated. Total liver volume (TLV) and spleen volume (Sp) were measured. Post-operatively, the histological Ishak fibrosis score was collected. Potential risk factors for liver failure were analysed, and the performance was examined by receiver operating characteristic curve. Results: Post-hepatectomy liver failure (PHLF) occurred in 16 patients (13.9%). TLV/SLV, ADC value, CERHBP/TP and total liver contrast enhancement ratio (tCER) were associated with PHLF (P <.05). Between PHLF and non-PHLF groups, remnant liver volume (RLV), RLV/SLV, Sp/RLV, remnant liver contrast enhancement ratio (rCER) and Ishak fibrosis score showed statistical difference. rCER showed superiority in diagnostic performance (AUC = 0.78) with the optimal cut-off value of 1.23. Conclusions: Gadoxetic acid-enhanced MR imaging with volumetric is a reliable method for evaluating functional liver volume and determining the risk of PHLF.

AB - Background & Aims: To assess the efficacy of functional MR image with volumetric, liver function test and indocyanine green clearance (ICG) in identifying the patients who are at risk of post-hepatectomy liver failure (PHLF). Methods: We retrospectively included 115 patients undergoing gadoxetic acid-enhanced MR imaging before hepatectomy at one medical centre from January 2013 to December 2015. Contrast enhancement ratio (CER) between transitional and hepatobiliary phases (3 and 30 minutes post-contrast) was calculated. Total liver volume (TLV) and spleen volume (Sp) were measured. Post-operatively, the histological Ishak fibrosis score was collected. Potential risk factors for liver failure were analysed, and the performance was examined by receiver operating characteristic curve. Results: Post-hepatectomy liver failure (PHLF) occurred in 16 patients (13.9%). TLV/SLV, ADC value, CERHBP/TP and total liver contrast enhancement ratio (tCER) were associated with PHLF (P <.05). Between PHLF and non-PHLF groups, remnant liver volume (RLV), RLV/SLV, Sp/RLV, remnant liver contrast enhancement ratio (rCER) and Ishak fibrosis score showed statistical difference. rCER showed superiority in diagnostic performance (AUC = 0.78) with the optimal cut-off value of 1.23. Conclusions: Gadoxetic acid-enhanced MR imaging with volumetric is a reliable method for evaluating functional liver volume and determining the risk of PHLF.

KW - Gd-EOB-DTPA MRI

KW - Post-hepatectomy liver failure

KW - cirrhosis

KW - contrast enhancement ratio

UR - https://www.scopus.com/pages/publications/85045994820

U2 - 10.1111/liv.13608

DO - 10.1111/liv.13608

M3 - 文章

C2 - 28987012

AN - SCOPUS:85045994820

SN - 1478-3223

VL - 38

SP - 868

EP - 874

JO - Liver International

JF - Liver International

IS - 5

ER -

Predicting post-hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis

Abstract

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Keywords

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