Abstract
BACKGROUND: To analyze multiple imaging modalities in patients with Bietti crystalline dystrophy (BCD) and to investigate which factors from these modalities are associated with best corrected visual acuity (BCVA). METHODS: In this retrospective study, 40 eyes from 22 patients with BCD were included and were separated into group 1 (BCVA ≤20/200) and group 2 (BCVA > 20/200). Data including BCVA and characteristic findings from near-infrared reflectance (NIR) imaging, fundus autofluorescence (FAF), and spectral domain-optic coherence tomography (SD-OCT) were analyzed and compared. The outcome measures of multimodal imaging were evaluated for correlation with BCVA. RESULTS: NIR is a good diagnostic tool for detecting either crystalline or sclerotic vessels in BCD. Patients in group 1 tended to have a thinner choroid (P = 0.047) with ellipsoid zone (EZ) disruption (P = 0.011). Calculation of the area under the curve indicated that EZ disruption detected on SD-OCT could be a good predictor of legal blindness in BCD. CONCLUSION: For the diagnosis of BCD, NIR could be a good diagnostic tool. Of the studied imaging modalities, we found that EZ disruption at the fovea were strongly associated with legal blindness, which could be easily assessed by SD-OCT.
Original language | English |
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Pages (from-to) | 68 |
Number of pages | 1 |
Journal | BMC Ophthalmology |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - 04 02 2021 |
Keywords
- Best corrected visual acuity (BCVA)
- Bietti crystalline dystrophy (BCD)
- Choroidal thickness
- Crystalline
- Ellipsoid zone disruption
- Fundus autofluorescence (FAF)
- Near-infrared reflectance (NIR)
- Sclerotic vessels
- Spectral domain-optical coherence tomography (SD-OCT)