Prediction of visual outcomes by an artificial neural network following intravitreal injection and laser therapy for retinopathy of prematurity

Ching Yen Huang, Ren Jieh Kuo, Cheng Han Li, Daniel S. Ting, Eugene Yu Chuan Kang, Chi Chun Lai, Hsiao Jung Tseng, Lan Yan Yang, Wei Chi Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations

Abstract

Aims To construct a program to predict the visual acuity (VA), best corrected VA (BCVA) and spherical equivalent (SE) of patients with retinopathy of prematurity (ROP) from 3 to 12 years old after intravitreal injection (IVI) of anti-vascular endothelial growth factor and/or laser photocoagulation treatment. Methods This retrospective study employed a feedforward artificial neural network with an error backpropagation learning algorithm to predict visual outcomes based on patient birth data, treatment received and age at follow-up. Patients were divided into two groups based on prior treatments. The main outcome measures were the difference between the predicted and actual values of visual outcomes. These were analysed using the normalised root mean square error (RMSE). Two-way repeated measures analysis of variance was used to compare the predictive accuracy by this algorithm. Results A total of 60 ROP infants with prior treatments were included. In the IVI group, the normalised average RMSE for VA, BCVA, and SE was 0.272, 0.185 and 0.131, respectively. In the laser group, the normalised average RMSE for VA, BCVA and SE was 0.190, 0.250 and 0.104, respectively. This result shows that better predictive power was obtained for SE than for VA or BCVA in both the IVI and laser groups (p<0.001). In addition, the algorithm performed slightly better in predicting visual outcomes in the laser group (p<0.001). Conclusions This algorithm offers acceptable power for predicting visual outcomes in patients with ROP with prior treatment. Predictions of SE were more precise than predictions of for VA and BCVA in both groups.

Original languageEnglish
Pages (from-to)1277-1282
Number of pages6
JournalBritish Journal of Ophthalmology
Volume104
Issue number9
DOIs
StatePublished - 01 09 2020

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Keywords

  • retina
  • vision

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