Predictive factors for lymph node metastasis in early gastric cancer

Chang Mu Sung, Chen Ming Hsu, Jun Te Hsu, Ta Sen Yeh, Chun Jung Lin, Tse Ching Chen, Ming Yao Su, Cheng Tang Chiu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

29 Scopus citations


AIM: To analyze the predictive factors for lymph node metastasis (LNM) in early gastric cancer (EGC). METHODS: Data from patients surgically treated for gastric cancers between January 1994 and December 2007 were retrospectively collected. Clinicopathological factors were analyzed to identify predictive factors for LNM. RESULTS: Of the 2936 patients who underwent gastrectomy and lymph node dissection, 556 were diagnosed with EGC and included in this study. Among these, 4.1% of patients had mucosal tumors (T1a) with LNM while 24.3% of patients had submucosal tumors with LNM. Univariate analysis found that female gender, tumors ≥ 2 cm, tumor invasion to the submucosa, vascular and lymphatic involvement were significantly associated with a higher rate of LNM. On multivariate analysis, tumor size, lymphatic involvement, and tumor with submucosal invasion were associated with LNM. CONCLUSION: Tumor with submucosal invasion, size ≥ 2 cm, and presence of lymphatic involvement are predictive factors for LNM in EGC.

Original languageEnglish
Pages (from-to)5252-5256
Number of pages5
JournalWorld Journal of Gastroenterology
Issue number41
StatePublished - 07 11 2010


  • Depth of tumor invasion
  • Early gastric cancer
  • Endoscopic submucosa dissection
  • Endoscopic treatment
  • Lymph node metastasis


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