Predictors and long-term outcome of seizures in human immuno-deficiency virus (HIV)-negative cryptococcal meningitis

Chih Wei Hung, Wen Neng Chang, Chia Te Kung, Nai Wen Tsai, Hung Chen Wang, Wei Che Lin, Chi Ren Huang, Chih Cheng Huang, Wan Chen Tsai, Hsueh Wen Chang, Yu Jih Su, Yu Jun Lin, Ben Chung Cheng, Ya Ting Chang, Chih Min Su, Cheng Hsien Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations


Background: Seizures are one of the most important neurologic complications of human immuno-deficiency virus (HIV)-negative cryptococcal meningitis. A better understanding of the risk associated factors can help predict those who will require treatment. Methods: This 22-year retrospective study enrolled 180 patients. Prognostic variables independently associated with seizures or fatality were analyzed using stepwise logistic regression. Results: Twenty-eight patients with HIV-negative cryptococcal meningitis had seizures, including 13 with early seizures and 15 with late seizures. The mean time interval from HIV-negative cryptococcal meningitis to first seizure in the early and late seizure groups were 1.5 and 51.4 days, respectively. Nine out of the 28 cases (32%) occurred within 24 hours of presentation. The overall mortality rate was 54% (15/28) and two patients progressed to epilepsy. Conclusions: Patients with seizure have worse outcomes and longer hospitalization. Most first seizures occur within one year after the diagnosis of HIV-negative cryptococcal meningitis.

Original languageEnglish
Article number208
JournalBMC Neurology
Issue number1
StatePublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 Hung et al.


  • HIV-negative cryptococcal meningitis
  • Outcome
  • Risk factors
  • Seizures


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