Predictors and outcome of seizures after spontaneous intracerebral hemorrhage: Clinical article

Tzu Ming Yang, Wei Che Lin, Wen Neng Chang, Jih Tsun Ho, Hung Chen Wang, Nai Wen Tsai, Yi Ting Shih, Cheng Hsien Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

52 Scopus citations

Abstract

Object. Seizures are an important neurological complication of spontaneous intracerebral hemorrhage (ICH). A better understanding of the risk factors of seizures following ICH is needed to predict which patients will require treatment. Methods. Two hundred and forty-three adult patients were enrolled in this 1-year retrospective study. Multiple logistic regression was used to evaluate the relationship between baseline clinical factors and the presence or absence of seizure during the study period. Results. Seizures occurred in 20 patients with ICH, including acute symptomatic seizures in 9 and unprovoked seizures in 11. None progressed to status epilepticus during hospitalization. After a minimum 3-year follow-up period, the mean Glasgow Outcome Scale score was 3.8 ± 1.1 for patients who had had seizures and 3.5 ± 1.3 for those who had not. The multiple logistic regression model demonstrated that the mean ICH volume was independently as sociated with seizures, and any increase of 1 mm3 in ICH volume increased the seizure rate by 2.7%. Conclusions. Higher mean ICH volumes at presentation were predictive of seizure, and the presence of late seizures was predictive of developing epilepsy. Most seizures occurred within 2 years of spontaneous ICH over a minimum of 3 years of follow-up.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalJournal of Neurosurgery
Volume111
Issue number1
DOIs
StatePublished - 07 2009

Keywords

  • Outcome
  • Risk factor
  • Seizure
  • Spontaneous intracerebral hemorrhage

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