Prenatal exposure to bisphenol-A is associated with Toll-like receptor-induced cytokine suppression in neonates

Sui Ling Liao, Ming Han Tsai, Shen Hao Lai, Tsung Chieh Yao, Man Chin Hua, Kuo Wei Yeh, Chi Hsin Chiang, Shih Yin Huang, Jing Long Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

40 Scopus citations


Background:Despite widespread human exposure to biphenol A (BPA), limited studies exist on the association of BPA with adverse health outcomes in young children. This study aims to investigate the effect of prenatal exposure to BPA on toll-like receptor-induced cytokine responses in neonates and its association with infectious diseases later in life.Methods:Cord bloods were collected from 275 full-term neonates. Production of TNF-α, IL-6, and IL-10 were evaluated after stimulating mononuclear cells with toll-like receptor ligands (TLR1-4 and 7-8). Serum BPA concentrations were analyzed by enzyme-linked immunosorbent assay. Bacteria from nasopharyngeal specimens were identified with multiplex PCR and culture method.Result:Result showed significant association between cord BPA concentration and TLR3- and TLR4-stimulated TNF-α response (P = 0.001) and that of TLR78-stimulated IL-6 response (P = 0.03). Clinical analysis did not show prenatal BPA exposure to be correlated with infection or bacterial colonization during the first year of life.Conclusion:This is the first cohort study that indicated prenatal BPA exposure to play a part in TLR-related innate immune response of neonatal infants. However, despite an altered immune homeostasis, result did not show such exposure to be associated with increased risk of infection during early infancy.

Original languageEnglish
Pages (from-to)438-444
Number of pages7
JournalPediatric Research
Issue number3
StatePublished - 01 03 2016

Bibliographical note

Publisher Copyright:
© 2016 International Pediatric Research Foundation, Inc.


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