Preoperative Transient Elastography in Patients with Esophageal Cancer

Tzu Yi Yang, Chia Pang Shih, Pei Ching Huang, Chun Yi Tsai*, Yin Kai Chao

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Since excessive alcohol consumption is a shared risk factor for esophageal cancer and liver fibrosis, it is possible that patients with esophageal cancer may develop unknown liver fibrosis or cirrhosis. We applied preoperative transient elastography (TE) to patients without recorded cirrhosis undergoing esophagectomy to clarify the validity in predicting postesophagectomy hepatic failure. The cohort consisted of 107 patients who received TE before esophagectomy between June 2018 and December 2021. Patients were categorized into two groups based on the fibrosis score yielded by preoperative TE (mild group: 0~2, n = 92; severe group: 3~4, n = 15). There was no significant difference in demographic data nor surgical variables between the two groups. None of the cohort encountered hepatic failure, yet the severe fibrosis group had a significantly higher rate of pleural effusion (40.0% versus 15.2%, p = 0.03). The areas under the curve (AUCs) of TE in predicting postoperative complications and 180-day mortality were 0.60 (95% CI: 0.46–0.74) and 0.67 (95% CI: 0.51–0.83), respectively. In conclusion, stratification of patients with esophageal cancer who had liver fibrosis by preoperative TE demonstrates significant validity in predicting postoperative pleural effusions. Recruitment of noncirrhotic patients with higher TE scores is warranted to examine its power in other parameters.

Original languageEnglish
Article number3194
Issue number12
StatePublished - 12 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.


  • alcoholic cirrhosis
  • esophageal cancer
  • esophagectomy
  • hepatic failure
  • indocyanine green
  • postoperative complications
  • transient elastography


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