TY - JOUR
T1 - Preparation and characterization of ferulic acid-modified water soluble chitosan and poly (γ-glutamic acid) polyelectrolyte films through layer-by-layer assembly towards protein adsorption
AU - Panda, Pradeep Kumar
AU - Yang, Jen Ming
AU - Chang, Yen Hsiang
N1 - Publisher Copyright:
© 2021
PY - 2021/2/28
Y1 - 2021/2/28
N2 - In this study, ferulic acid-modified water soluble chitosan and poly (γ-glutamic acid) polyelectrolyte multilayers films were constructed through the layer-by-layer (LBL) self-assembly technique. Chitosan (CS) or ferulic acid modified chitosan (MCS) and Poly (γ-glutamic acid) (PGA) was alternately deposited on the surface of glass substrate for the enhancement of surface modification. The obtained films were characterized by Fourier transform spectroscopy (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), UV–vis spectroscopy and water contact angle to study its physico-chemical properties including protein absorption. The (PGA/MCS) films showed intense deposition of multilayers built upon the surface roughness and an increase in the exponential growth of multilayer films by UV–vis spectroscopy. Water contact angle indicated that the (PGA/MCS) films performed well with good wettability due to the increase in the number of layers. The LBL multilayer coatings of (PGA/MCS) films surface possessed a reduced amount of protein adsorption. These results indicated that it can resist the protein adsorption and can enhance the biocompatibility towards the biomedical application through the protein interaction. The (PGA/MCS) films has the potential to utilization as a good biomaterial for biomedical purposes to intensify the bio-active surface.
AB - In this study, ferulic acid-modified water soluble chitosan and poly (γ-glutamic acid) polyelectrolyte multilayers films were constructed through the layer-by-layer (LBL) self-assembly technique. Chitosan (CS) or ferulic acid modified chitosan (MCS) and Poly (γ-glutamic acid) (PGA) was alternately deposited on the surface of glass substrate for the enhancement of surface modification. The obtained films were characterized by Fourier transform spectroscopy (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), UV–vis spectroscopy and water contact angle to study its physico-chemical properties including protein absorption. The (PGA/MCS) films showed intense deposition of multilayers built upon the surface roughness and an increase in the exponential growth of multilayer films by UV–vis spectroscopy. Water contact angle indicated that the (PGA/MCS) films performed well with good wettability due to the increase in the number of layers. The LBL multilayer coatings of (PGA/MCS) films surface possessed a reduced amount of protein adsorption. These results indicated that it can resist the protein adsorption and can enhance the biocompatibility towards the biomedical application through the protein interaction. The (PGA/MCS) films has the potential to utilization as a good biomaterial for biomedical purposes to intensify the bio-active surface.
KW - Chitosan
KW - Layer-by-layer self-assembly
KW - Modified chitosan
KW - Poly (γ-glutamic acid)
KW - Polyelectrolyte multilayers
KW - Protein adsorption
UR - http://www.scopus.com/inward/record.url?scp=85099483396&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2020.12.226
DO - 10.1016/j.ijbiomac.2020.12.226
M3 - 文章
C2 - 33421474
AN - SCOPUS:85099483396
SN - 0141-8130
VL - 171
SP - 457
EP - 464
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -