Preparation of β-cyclodextrin entrapped graphite composite for sensitive detection of dopamine

A simple dopamine (DA) electrochemical sensor was developed based on a screen-printed carbon electrode (SPCE) modified with β-cyclodextrin entrapped graphite (GR/β-CD) composite for the first time. The polar hydroxyl groups on the β-CD rims interact with polar groups of edges of GR sheets resulting into the high dispersion ability of GR in β-CD solution. The GR/β-CD modified electrode exhibited a higher electrochemical response to DA with a lower oxidation potential (0.224 V) than that of bare/β-CD (0.38 V) and GR (0.525 V) modified SPCEs, revealing an excellent electro-oxidation behavior of GR/β-CD composite toward DA. Under optimum conditions, the fabricated sensor detects the DA in the linear concentration range from 0.1 to 58.5 μM with a limit of detection of 0.011 μM and the sensitivity of 1.27 ± 0.02 μA μM^-1 cm^-2. The fabricated sensor also exhibits the excellent repeatability, practicality, reproducibility, storage stability along with acceptable selectivity. 7copy; 2015 Elsevier Ltd. All rights reserved.