@inproceedings{249453bd5f514aac869651e917dd4869,
title = "Preparation of biomimetic nanofibers by electrospinning of blends of silk fibroin and chitosan for bone tissue engineering",
abstract = "In this study, we have successfully fabricated electrospun bead-free silk fibroin (SF)/chitosan (CS) blend nanofibers (NFs) covering the whole range of CS content (0, 25, 50, 75, and 100%). NFs are treated with ethanol/ammonia aqueous solution to remove residual TFA and to change SF protein conformation. After the chemical treatment, SF/CS NFs could maintain the original structure for up to 54 days in culture medium. Human fetal osteoblast progenitor (hFOB) cells were capable of proliferating and osteogenic differentiating on SF/CS NFs from MTS and alkaline phosphatase assays. SF enhanced hFOB proliferation while CS enhanced hFOB differentiation. The prepared SF/CS blend NFs will be suitable for tissue engineering applications.",
keywords = "chitosan, electrospinning, nanofibers, silk fibroin, tissue engineering",
author = "Chen, {Shih Hsien} and Lai, {Guo Jyun} and Chen, {Jyh Ping}",
year = "2011",
doi = "10.1109/INEC.2011.5991742",
language = "英语",
isbn = "9781457703799",
series = "Proceedings - International NanoElectronics Conference, INEC",
booktitle = "4th IEEE International NanoElectronics Conference, INEC 2011",
note = "4th IEEE International Nanoelectronics Conference, INEC 2011 ; Conference date: 21-06-2011 Through 24-06-2011",
}