Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: A positron emission tomography study

H. Shinotoh; B. J. Snow; N. S. Chu; C. C. Huang; C. S. Lu; C. Lee; H. Takahashi; D. B. Calne

doi:10.1212/wnl.48.4.1053

Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: A positron emission tomography study

H. Shinotoh
, B. J. Snow
, N. S. Chu
, C. C. Huang
, C. S. Lu
, C. Lee
, H. Takahashi
, D. B. Calne^*

^*Corresponding author for this work

University of British Columbia
Chang Gung University
Vancouver Hospital and Health Sciences Center, Vancouver

Research output: Contribution to journal › Journal Article › peer-review

111 Scopus citations

Abstract

We performed PET on four patients with chronic industrial Mn intoxication; presynaptic and postsynaptic dopaminergic function were measured with [¹⁸F]6-fluoro-L-dopa (6FD) and [¹¹C]raclopride (RAC). All patients had a rigid-akinetic syndrome; they had no sustained benefit from L- dopa. Influx constants (Ki) of 6FD were normal in the caudate and putamen. RAC binding was mildly reduced in the caudate and normal in the putamen. We conclude that nigrostriatal dopaminergic dysfunction is not responsible for the parkinsonism caused by chronic Mn intoxication. The pathology is likely to be downstream of the dopaminergic projection.

Original language	English
Pages (from-to)	1053-1056
Number of pages	4
Journal	Neurology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1212/wnl.48.4.1053
State	Published - 04 1997
Externally published	Yes

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title = "Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: A positron emission tomography study",

abstract = "We performed PET on four patients with chronic industrial Mn intoxication; presynaptic and postsynaptic dopaminergic function were measured with [18F]6-fluoro-L-dopa (6FD) and [11C]raclopride (RAC). All patients had a rigid-akinetic syndrome; they had no sustained benefit from L- dopa. Influx constants (Ki) of 6FD were normal in the caudate and putamen. RAC binding was mildly reduced in the caudate and normal in the putamen. We conclude that nigrostriatal dopaminergic dysfunction is not responsible for the parkinsonism caused by chronic Mn intoxication. The pathology is likely to be downstream of the dopaminergic projection.",

author = "H. Shinotoh and Snow, \{B. J.\} and Chu, \{N. S.\} and Huang, \{C. C.\} and Lu, \{C. S.\} and C. Lee and H. Takahashi and Calne, \{D. B.\}",

year = "1997",

month = apr,

doi = "10.1212/wnl.48.4.1053",

language = "英语",

volume = "48",

pages = "1053--1056",

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TY - JOUR

T1 - Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication

T2 - A positron emission tomography study

AU - Shinotoh, H.

AU - Snow, B. J.

AU - Chu, N. S.

AU - Huang, C. C.

AU - Lu, C. S.

AU - Lee, C.

AU - Takahashi, H.

AU - Calne, D. B.

PY - 1997/4

Y1 - 1997/4

N2 - We performed PET on four patients with chronic industrial Mn intoxication; presynaptic and postsynaptic dopaminergic function were measured with [18F]6-fluoro-L-dopa (6FD) and [11C]raclopride (RAC). All patients had a rigid-akinetic syndrome; they had no sustained benefit from L- dopa. Influx constants (Ki) of 6FD were normal in the caudate and putamen. RAC binding was mildly reduced in the caudate and normal in the putamen. We conclude that nigrostriatal dopaminergic dysfunction is not responsible for the parkinsonism caused by chronic Mn intoxication. The pathology is likely to be downstream of the dopaminergic projection.

AB - We performed PET on four patients with chronic industrial Mn intoxication; presynaptic and postsynaptic dopaminergic function were measured with [18F]6-fluoro-L-dopa (6FD) and [11C]raclopride (RAC). All patients had a rigid-akinetic syndrome; they had no sustained benefit from L- dopa. Influx constants (Ki) of 6FD were normal in the caudate and putamen. RAC binding was mildly reduced in the caudate and normal in the putamen. We conclude that nigrostriatal dopaminergic dysfunction is not responsible for the parkinsonism caused by chronic Mn intoxication. The pathology is likely to be downstream of the dopaminergic projection.

UR - https://www.scopus.com/pages/publications/0030960663

U2 - 10.1212/wnl.48.4.1053

DO - 10.1212/wnl.48.4.1053

M3 - 文章

C2 - 9109899

AN - SCOPUS:0030960663

SN - 0028-3878

VL - 48

SP - 1053

EP - 1056

JO - Neurology

JF - Neurology

IS - 4

ER -

Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: A positron emission tomography study

Abstract

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