Pretreatment evaluation of distant-site status in patients with nasopharyngeal carcinoma: Accuracy of whole-body MRI at 3-Tesla and FDG-PET-CT

Shu Hang Ng; Sheng Chieh Chan; Tzu Chen Yen; Joseph Tung Chieh Chang; Chun Ta Liao; Sheung Fat Ko; Hung Ming Wang; Yau Yau Wai; Jiun Jie Wang; Min Chi Chen

doi:10.1007/s00330-009-1504-5

Pretreatment evaluation of distant-site status in patients with nasopharyngeal carcinoma: Accuracy of whole-body MRI at 3-Tesla and FDG-PET-CT

Shu Hang Ng^*, Sheng Chieh Chan, Tzu Chen Yen, Joseph Tung Chieh Chang, Chun Ta Liao, Sheung Fat Ko, Hung Ming Wang, Yau Yau Wai, Jiun Jie Wang, Min Chi Chen

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

35 Scopus citations

Abstract

We sought to prospectively evaluate the accuracy of 3.0-Tesla whole-body magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the assessment of distant-site status in 150 patients with untreated nasopharyngeal carcinoma (NPC). Eighteen (12%) patients were diagnosed as having distant malignancies (15 patients had distant metastases, and three distant synchronous tumours). On a patient-based analysis, WB-MRI and FDG-PET-CT showed similar sensitivity (77.8% vs 72.2%, P>0.999), specificity (98.5% vs 97.7%, P>0.999) and diagnostic capability (0.905 vs 0.878, P=0.669). Combined interpretation of WB-MRI and FDG-PET-CT showed no significant benefit over either technique alone. In conclusion, 3.0-Tesla WB-MRI is a feasible, non-ionising technique that showed similar diagnostic capacity to FDG-PET-CT in assessing distant-site status in patients with untreated NPC and can be recommended as the first-line imaging technique for comprehensive evaluation of such patients.

Original language	English
Pages (from-to)	2965-2976
Number of pages	12
Journal	European Radiology
Volume	19
Issue number	12
DOIs	https://doi.org/10.1007/s00330-009-1504-5
State	Published - 12 2009

Keywords

Computed tomography
Magnetic resonance imaging
Nasopharyngeal carcinoma
Positron emission tomography
Whole body

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title = "Pretreatment evaluation of distant-site status in patients with nasopharyngeal carcinoma: Accuracy of whole-body MRI at 3-Tesla and FDG-PET-CT",

abstract = "We sought to prospectively evaluate the accuracy of 3.0-Tesla whole-body magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the assessment of distant-site status in 150 patients with untreated nasopharyngeal carcinoma (NPC). Eighteen (12\%) patients were diagnosed as having distant malignancies (15 patients had distant metastases, and three distant synchronous tumours). On a patient-based analysis, WB-MRI and FDG-PET-CT showed similar sensitivity (77.8\% vs 72.2\%, P>0.999), specificity (98.5\% vs 97.7\%, P>0.999) and diagnostic capability (0.905 vs 0.878, P=0.669). Combined interpretation of WB-MRI and FDG-PET-CT showed no significant benefit over either technique alone. In conclusion, 3.0-Tesla WB-MRI is a feasible, non-ionising technique that showed similar diagnostic capacity to FDG-PET-CT in assessing distant-site status in patients with untreated NPC and can be recommended as the first-line imaging technique for comprehensive evaluation of such patients.",

keywords = "Computed tomography, Magnetic resonance imaging, Nasopharyngeal carcinoma, Positron emission tomography, Whole body",

author = "Ng, \{Shu Hang\} and Chan, \{Sheng Chieh\} and Yen, \{Tzu Chen\} and Chang, \{Joseph Tung Chieh\} and Liao, \{Chun Ta\} and Ko, \{Sheung Fat\} and Wang, \{Hung Ming\} and Wai, \{Yau Yau\} and Wang, \{Jiun Jie\} and Chen, \{Min Chi\}",

year = "2009",

month = dec,

doi = "10.1007/s00330-009-1504-5",

language = "英语",

volume = "19",

pages = "2965--2976",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "12",

}

TY - JOUR

T1 - Pretreatment evaluation of distant-site status in patients with nasopharyngeal carcinoma

T2 - Accuracy of whole-body MRI at 3-Tesla and FDG-PET-CT

AU - Ng, Shu Hang

AU - Chan, Sheng Chieh

AU - Yen, Tzu Chen

AU - Chang, Joseph Tung Chieh

AU - Liao, Chun Ta

AU - Ko, Sheung Fat

AU - Wang, Hung Ming

AU - Wai, Yau Yau

AU - Wang, Jiun Jie

AU - Chen, Min Chi

PY - 2009/12

Y1 - 2009/12

N2 - We sought to prospectively evaluate the accuracy of 3.0-Tesla whole-body magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the assessment of distant-site status in 150 patients with untreated nasopharyngeal carcinoma (NPC). Eighteen (12%) patients were diagnosed as having distant malignancies (15 patients had distant metastases, and three distant synchronous tumours). On a patient-based analysis, WB-MRI and FDG-PET-CT showed similar sensitivity (77.8% vs 72.2%, P>0.999), specificity (98.5% vs 97.7%, P>0.999) and diagnostic capability (0.905 vs 0.878, P=0.669). Combined interpretation of WB-MRI and FDG-PET-CT showed no significant benefit over either technique alone. In conclusion, 3.0-Tesla WB-MRI is a feasible, non-ionising technique that showed similar diagnostic capacity to FDG-PET-CT in assessing distant-site status in patients with untreated NPC and can be recommended as the first-line imaging technique for comprehensive evaluation of such patients.

AB - We sought to prospectively evaluate the accuracy of 3.0-Tesla whole-body magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the assessment of distant-site status in 150 patients with untreated nasopharyngeal carcinoma (NPC). Eighteen (12%) patients were diagnosed as having distant malignancies (15 patients had distant metastases, and three distant synchronous tumours). On a patient-based analysis, WB-MRI and FDG-PET-CT showed similar sensitivity (77.8% vs 72.2%, P>0.999), specificity (98.5% vs 97.7%, P>0.999) and diagnostic capability (0.905 vs 0.878, P=0.669). Combined interpretation of WB-MRI and FDG-PET-CT showed no significant benefit over either technique alone. In conclusion, 3.0-Tesla WB-MRI is a feasible, non-ionising technique that showed similar diagnostic capacity to FDG-PET-CT in assessing distant-site status in patients with untreated NPC and can be recommended as the first-line imaging technique for comprehensive evaluation of such patients.

KW - Computed tomography

KW - Magnetic resonance imaging

KW - Nasopharyngeal carcinoma

KW - Positron emission tomography

KW - Whole body

UR - https://www.scopus.com/pages/publications/71449090898

U2 - 10.1007/s00330-009-1504-5

DO - 10.1007/s00330-009-1504-5

M3 - 文章

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AN - SCOPUS:71449090898

SN - 0938-7994

VL - 19

SP - 2965

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JO - European Radiology

JF - European Radiology

IS - 12

ER -

Pretreatment evaluation of distant-site status in patients with nasopharyngeal carcinoma: Accuracy of whole-body MRI at 3-Tesla and FDG-PET-CT

Abstract

Keywords

UN SDGs

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