Prevalence of hypertension after living-donor liver transplantation: A prospective study

M. S. Tong, H. T. Chai, W. H. Liu, C. L. Chen, M. Fu, Y. H. Lin, C. C. Lin, S. M. Chen*, C. L. Hang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations

Abstract

Background Hypertension is common among patients who have undergone liver transplantation and is a major contributor to cardiovascular events. Few studies have studied the risk factors associated with post-liver transplantation (LT) hypertension. This prospective study assessed the prevalence of post-LT hypertension and associated preoperative risk factors. Methods From May 2008 to December 2009, 79 normotensive adult patients (≥18 years old) who underwent living-donor LT with a median follow up of 4.79 ± 0.88 years were enrolled. Patients' pre-LT demographics, clinical data, pre-LT diabetes, and immunosuppressive agents used after LT were studied for their association with post-LT hypertension. Results The prevalence of post-LT hypertension was 49.4%. The independent risk factors for post-living-donor LT hypertension were pre-LT systolic blood pressure (SBP; odds ratio [OR], 1.04; 95% confidence interval [CI], 1.00-1.09; P =.039) and post-LT administration of mammalian target of rapamycin (mTOR) inhibitors (OR, 4.08; 95% CI, 1.40-11.94; P =.010). Pre-LT diabetes had a negative predictive value (OR, 0.15; 95% CI, 0.03-0.74; P =.019). Neither age, male sex, smoking, pre-LT serum cholesterol and triglyceride levels, tacrolimus, nor glucocorticoid was associated with post-LT hypertension. Conclusions The prevalence of hypertension is high after LT. Higher pre-LT SBP and post-LT mTOR inhibitor administration predispose patients to post-LT hypertension.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalTransplantation Proceedings
Volume47
Issue number2
DOIs
StatePublished - 01 03 2015
Externally publishedYes

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© 2015 Elsevier Inc. All rights reserved.

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