Primary carcinoma of the gallbladder in Taiwan

Tzu Chieh Chao*, Chia Siu Wang, Long Bin Jeng, Yi Yin Jan, Miin Fu Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

24 Scopus citations


To define more precisely the prognostic index for patients with primary carcinoma of the gallbladder in Taiwan, we retrospectively reviewed the data of 74 patients with gallbladder carcinoma treated over a period of 15 years, from 1979 to 1993. Of these patients, 75% had Nevin stage V gallbladder cancer. The most common presenting complaint was abdominal pain, followed by jaundice, fever, and nausea and vomiting. Accurate preoperative diagnosis was made in 29.7% of the patients. Ultrasonography and computed tomography had a diagnostic accuracy of 34.0% and 40.9%, respectively. The most common histologic type was adenocarcinoma. Liver was the organ most commonly invaded (51.9%) by direct extension and/or metastases, followed by regional lymph nodes (38.5%). The overall 5-year survival rate was 4.1%. Age, sex, white cell count, hemoglobulin, SGOT, SGPT, total bilirubin, alkaline phosphatase, and cholelithiasis were not significant prognostic factors. Patients with cancers confined in the gallbladder wall (stages I, II, III) had a better (P < 0.05) cumulative survival rate than did those with regional lymph nodes and distant metastases. Cholecystectomy or extended surgery had a better survival rate than did palliative surgery, but there was no significant difference between cholecystectomy and extended surgery. High index of suspicion of the disease and earlier surgical treatment may improve patient survival.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalJournal of Surgical Oncology
Issue number1
StatePublished - 01 1996
Externally publishedYes


  • cholecystectomy
  • cholelithiasis
  • gallbladder carcinoma
  • ultrasonography


Dive into the research topics of 'Primary carcinoma of the gallbladder in Taiwan'. Together they form a unique fingerprint.

Cite this