Primary glioblastoma multiforme in the pineal region: A case report with diagnostic imaging findings, treatment response, and literature review

Glioblastoma multiforme (GBM) is one of the most common primary tumors of the central nervous system, comprising up to half of all primary brain tumors; however, primary GBM of the pineal region is extremely rare. To our knowledge, there are only 18 reported cases. We report a rare case of pineal GBM in a 32-year-old male who presented with headache, visual image distortion, and vertigo. Computed tomography, magnetic resonance imaging, and cerebral angiography revealed a tumor mass in the pineal region. The mass was diagnosed as a glioblastoma following subtotal removal. After combined surgery and concurrent chemoradiotherapy treatment, our patient survived longer than 1 year after the initial diagnosis. Here, we present the radiographic features and treatment strategy of pineal GBM, with a review of the literature.