TY - JOUR
T1 - Primary small-intestinal lymphomas in Taiwan
T2 - Immunoproliferative small-intestinal disease and nonimmunoproliferative small-intestinal disease
AU - Shih, Lee Yung
AU - Liaw, Shiumn Jen
AU - Dunn, Po
AU - Kuo, Tseng Tong
PY - 1994/7
Y1 - 1994/7
N2 - Purpose: The clinicopathologic findings in 45 adult Chinese patients with primary small-intestinal lymphoma (PSIL) are described and compared with those in Western countries and in underdeveloped nations. The efficacy of combination chemotherapy is also assessed. Patients and Methods: Six patients had immunoproliferative small-intestinal disease (IPSID) indicated by the presence of α-heavy chain protein (α-CP) in body fluids or tumor tissues. Thirty-nine patients had non-IPSID, including one with postrenal transplant lymphoma. Thirty-three non-IPSID patients received a minimum of four cycles of combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Results: All IPSID patients presented with the clinical and laboratory features of severe intestinal malabsorption, and all had diffuse lymphoplasmacytic infiltration in the mucosa of the small bowel. Lymphomas were localized mainly in the jejunum and mesenteric nodes. The histologic subtypes were diffuse large cell in two, immunoblastic in three, and diffuse mixed in one. All patients responded poorly to chemotherapy, with a median survival duration of 10.5 months. The common presenting symptoms of the 39 non-IPSID patients included abdominal pain (90%), weight loss (31%), abdominal mass (26%), obstruction (26%), and perforation (23%). Diffuse large-cell and immunoblastic lymphomas constituted 82% of cases. Four patients had stage IE, 19 stage II1E, and 16 stage II2E disease according to the Musshoff's criteria; 22 had bulky tumors and 19 had multiple tumors. The tumors were completely resected in 14 patients. Of 33 patients treated with combination chemotherapy, 73% achieved a complete remission. With a median follow-up duration of 90 months, there have been four relapses, with only one at the primary tumor site. The overall 5-year survival and disease-free survival rates for non-IPSID patients who were treated with chemotherapy were 59% and 54%, respectively. Conclusion: Intensive chemotherapy produces long-term disease-free survival in locally advanced non-IPSID PSIL.
AB - Purpose: The clinicopathologic findings in 45 adult Chinese patients with primary small-intestinal lymphoma (PSIL) are described and compared with those in Western countries and in underdeveloped nations. The efficacy of combination chemotherapy is also assessed. Patients and Methods: Six patients had immunoproliferative small-intestinal disease (IPSID) indicated by the presence of α-heavy chain protein (α-CP) in body fluids or tumor tissues. Thirty-nine patients had non-IPSID, including one with postrenal transplant lymphoma. Thirty-three non-IPSID patients received a minimum of four cycles of combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Results: All IPSID patients presented with the clinical and laboratory features of severe intestinal malabsorption, and all had diffuse lymphoplasmacytic infiltration in the mucosa of the small bowel. Lymphomas were localized mainly in the jejunum and mesenteric nodes. The histologic subtypes were diffuse large cell in two, immunoblastic in three, and diffuse mixed in one. All patients responded poorly to chemotherapy, with a median survival duration of 10.5 months. The common presenting symptoms of the 39 non-IPSID patients included abdominal pain (90%), weight loss (31%), abdominal mass (26%), obstruction (26%), and perforation (23%). Diffuse large-cell and immunoblastic lymphomas constituted 82% of cases. Four patients had stage IE, 19 stage II1E, and 16 stage II2E disease according to the Musshoff's criteria; 22 had bulky tumors and 19 had multiple tumors. The tumors were completely resected in 14 patients. Of 33 patients treated with combination chemotherapy, 73% achieved a complete remission. With a median follow-up duration of 90 months, there have been four relapses, with only one at the primary tumor site. The overall 5-year survival and disease-free survival rates for non-IPSID patients who were treated with chemotherapy were 59% and 54%, respectively. Conclusion: Intensive chemotherapy produces long-term disease-free survival in locally advanced non-IPSID PSIL.
UR - http://www.scopus.com/inward/record.url?scp=0028284417&partnerID=8YFLogxK
U2 - 10.1200/JCO.1994.12.7.1375
DO - 10.1200/JCO.1994.12.7.1375
M3 - 文章
C2 - 8021727
AN - SCOPUS:0028284417
SN - 0732-183X
VL - 12
SP - 1375
EP - 1382
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 7
ER -