Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis

Chun Kai Liao, Jy Ming Chiang, Wen Sy Tsai, Jeng Fu You, Pao Shiu Hsieh, Hsin Yuan Hung, Hong Hwa Chen, Rei Ping Tang, Jinn Shiun Chen, Chien Yuh Yeh*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations

Abstract

Background and Objectives: We aim to investigate whether a difference exists between right-sided and left-sided colon cancer at the same disease stage and subsequent liver metastasis and identify whether tumor location can independently influence survival. Methods: Right-sided colon cancer was defined as malignancy arising from the cecum to the transverse colon; left-sided colon cancer was defined as malignancy arising from the splenic flexure to the sigmoid colon. Clinicopathological features and survival data were collected for analysis. Results: Overall, 1442 patients were included for analysis. The median follow-up time was 58.2 months. Patients with left-sided colon cancer had better 5-year overall survival (75.2% vs 61.7%, P = 0.005), 5-year cancer-specific survival (81.6% vs 73.4%, P = 0.001), and 5-year recurrence-free survival (70.9% vs 66.5%, P = 0.033) compared with patients having right-sided colon cancer. After the presentation of subsequent liver metastasis, patients with primary left-sided colon cancer had better 3-year cancer-specific survival (P < 0.001). In the multivariate analysis, cancer location was an independent prognostic factor for cancer-specific survival (right vs left, HR: 1.276, 95% CI: 1.002-1.625). Conclusions: The primary tumor location can serve as a prognostic factor for treatment outcomes either in primary stage III colon cancer or subsequent liver metastasis.

Original languageEnglish
Pages (from-to)1301-1310
Number of pages10
JournalJournal of Surgical Oncology
Volume118
Issue number8
DOIs
StatePublished - 15 12 2018

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

Keywords

  • colon cancer
  • left
  • liver metastasis
  • location
  • outcome
  • right

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