Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.

Toshio Kokuryo; Tatsuyoshi Yamamoto; Koji Oda; Junichi Kamiya; Yuji Nimura; Takeshi Senga; Yoshinari Yasuda; Yoshiyuki Ohno; Yasuni Nakanuma; Miin Fu Chen; Yi Yin Jan; Ta Sen Yeh; Cheng Taug Chiu; Ling Ling Hsieh; Michinari Hamaguchi

doi:10.3892/ijo.22.1.175

Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.

Toshio Kokuryo^*, Tatsuyoshi Yamamoto, Koji Oda, Junichi Kamiya, Yuji Nimura, Takeshi Senga, Yoshinari Yasuda, Yoshiyuki Ohno, Yasuni Nakanuma, Miin Fu Chen, Yi Yin Jan, Ta Sen Yeh, Cheng Taug Chiu, Ling Ling Hsieh, Michinari Hamaguchi

^*Corresponding author for this work

Nagoya University

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

By use of cDNA expression array method, we compared the expression profiles of genes in hepatolithiasis tissues with those of paired normal tissues. Expression of 1176 cancer related genes that include 33 tumor suppressor genes, 100 proto-oncogenes and 37 DNA damage repair genes were examined in this study. We found that expression of tumor suppressor genes and proto-oncogenes was systemically activated in hepatholithiasis tissues, suggesting that expression of genes controlling cell growth becomes unstable in liver lobe of hepatolithiasis. In contrast, expression of DNA damage repair genes were not activated but rather remained unchanged in hepatholithiasis tissues, suggesting that repair process is not strongly activated but rather impaired in hepatholithiasis tissues.

Original language	English
Pages (from-to)	175-179
Number of pages	5
Journal	International Journal of Oncology
Volume	22
Issue number	1
DOIs	https://doi.org/10.3892/ijo.22.1.175
State	Published - 01 2003
Externally published	Yes

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Kokuryo, T., Yamamoto, T., Oda, K., Kamiya, J., Nimura, Y., Senga, T., Yasuda, Y., Ohno, Y., Nakanuma, Y., Chen, M. F., Jan, Y. Y., Yeh, T. S., Chiu, C. T., Hsieh, L. L., & Hamaguchi, M. (2003). Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array. International Journal of Oncology, 22(1), 175-179. https://doi.org/10.3892/ijo.22.1.175

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title = "Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.",

abstract = "By use of cDNA expression array method, we compared the expression profiles of genes in hepatolithiasis tissues with those of paired normal tissues. Expression of 1176 cancer related genes that include 33 tumor suppressor genes, 100 proto-oncogenes and 37 DNA damage repair genes were examined in this study. We found that expression of tumor suppressor genes and proto-oncogenes was systemically activated in hepatholithiasis tissues, suggesting that expression of genes controlling cell growth becomes unstable in liver lobe of hepatolithiasis. In contrast, expression of DNA damage repair genes were not activated but rather remained unchanged in hepatholithiasis tissues, suggesting that repair process is not strongly activated but rather impaired in hepatholithiasis tissues.",

author = "Toshio Kokuryo and Tatsuyoshi Yamamoto and Koji Oda and Junichi Kamiya and Yuji Nimura and Takeshi Senga and Yoshinari Yasuda and Yoshiyuki Ohno and Yasuni Nakanuma and Chen, {Miin Fu} and Jan, {Yi Yin} and Yeh, {Ta Sen} and Chiu, {Cheng Taug} and Hsieh, {Ling Ling} and Michinari Hamaguchi",

year = "2003",

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doi = "10.3892/ijo.22.1.175",

language = "英语",

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Kokuryo, T, Yamamoto, T, Oda, K, Kamiya, J, Nimura, Y, Senga, T, Yasuda, Y, Ohno, Y, Nakanuma, Y, Chen, MF, Jan, YY, Yeh, TS, Chiu, CT, Hsieh, LL & Hamaguchi, M 2003, 'Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.', International Journal of Oncology, vol. 22, no. 1, pp. 175-179. https://doi.org/10.3892/ijo.22.1.175

TY - JOUR

T1 - Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.

AU - Kokuryo, Toshio

AU - Yamamoto, Tatsuyoshi

AU - Oda, Koji

AU - Kamiya, Junichi

AU - Nimura, Yuji

AU - Senga, Takeshi

AU - Yasuda, Yoshinari

AU - Ohno, Yoshiyuki

AU - Nakanuma, Yasuni

AU - Chen, Miin Fu

AU - Jan, Yi Yin

AU - Yeh, Ta Sen

AU - Chiu, Cheng Taug

AU - Hsieh, Ling Ling

AU - Hamaguchi, Michinari

PY - 2003/1

Y1 - 2003/1

N2 - By use of cDNA expression array method, we compared the expression profiles of genes in hepatolithiasis tissues with those of paired normal tissues. Expression of 1176 cancer related genes that include 33 tumor suppressor genes, 100 proto-oncogenes and 37 DNA damage repair genes were examined in this study. We found that expression of tumor suppressor genes and proto-oncogenes was systemically activated in hepatholithiasis tissues, suggesting that expression of genes controlling cell growth becomes unstable in liver lobe of hepatolithiasis. In contrast, expression of DNA damage repair genes were not activated but rather remained unchanged in hepatholithiasis tissues, suggesting that repair process is not strongly activated but rather impaired in hepatholithiasis tissues.

AB - By use of cDNA expression array method, we compared the expression profiles of genes in hepatolithiasis tissues with those of paired normal tissues. Expression of 1176 cancer related genes that include 33 tumor suppressor genes, 100 proto-oncogenes and 37 DNA damage repair genes were examined in this study. We found that expression of tumor suppressor genes and proto-oncogenes was systemically activated in hepatholithiasis tissues, suggesting that expression of genes controlling cell growth becomes unstable in liver lobe of hepatolithiasis. In contrast, expression of DNA damage repair genes were not activated but rather remained unchanged in hepatholithiasis tissues, suggesting that repair process is not strongly activated but rather impaired in hepatholithiasis tissues.

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U2 - 10.3892/ijo.22.1.175

DO - 10.3892/ijo.22.1.175

M3 - 文章

C2 - 12469201

AN - SCOPUS:1842836634

SN - 1019-6439

VL - 22

SP - 175

EP - 179

JO - International Journal of Oncology

JF - International Journal of Oncology

IS - 1

ER -

Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.

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