TY - JOUR
T1 - Prognosis and feasibility of en-bloc vascular resection in stage II pancreatic adenocarcinoma
AU - Chakravarty, K. Dilip
AU - Hsu, Jun Te
AU - Liu, Keng Hao
AU - Yeh, Chun Nan
AU - Yeh, Ta Sen
AU - Hwang, Tsann Long
AU - Jan, Yi Yin
AU - Chen, Miin Fu
PY - 2010/2/28
Y1 - 2010/2/28
N2 - AIM: To establish the prognosis and feasibility of en-bloc vascular resection of stage II pancreatic adenocarcinoma of the head and uncinate process. METHODS: We retrospectively analyzed 87 patients with stage II pancreatic adenocarcinoma, who were subjected to pancreaticoduodenectomy (PD) and pylorus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital, Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV), respectively. RESULTS: The overall 1- and 3-year survival rates of patients undergoing PD/PPPD with and without vascular resection were 50.0% and 16.7%, and 44.4% and 12.2%, respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%, and 40.0% and 2.7%, respectively. In multivariate analysis, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors that influenced survival. CONCLUSION: In stage II adenocarcinoma of the pancreatic head and uncinate process, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors, and en-bloc vascular resection is a feasible option in carefully selected patients.
AB - AIM: To establish the prognosis and feasibility of en-bloc vascular resection of stage II pancreatic adenocarcinoma of the head and uncinate process. METHODS: We retrospectively analyzed 87 patients with stage II pancreatic adenocarcinoma, who were subjected to pancreaticoduodenectomy (PD) and pylorus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital, Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV), respectively. RESULTS: The overall 1- and 3-year survival rates of patients undergoing PD/PPPD with and without vascular resection were 50.0% and 16.7%, and 44.4% and 12.2%, respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%, and 40.0% and 2.7%, respectively. In multivariate analysis, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors that influenced survival. CONCLUSION: In stage II adenocarcinoma of the pancreatic head and uncinate process, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors, and en-bloc vascular resection is a feasible option in carefully selected patients.
KW - Adenocarcinoma
KW - Chemotherapy
KW - Pancreatic neoplasms
KW - Pancreaticoduodenectomy
KW - Portal vein
KW - Superior mesenteric vein
UR - https://www.scopus.com/pages/publications/77649257405
U2 - 10.3748/wjg.v16.i8.997
DO - 10.3748/wjg.v16.i8.997
M3 - 文章
C2 - 20180240
AN - SCOPUS:77649257405
SN - 1007-9327
VL - 16
SP - 997
EP - 1002
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 8
ER -
