Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer

Pei Hung Chang; Jason Chia Hsun Hsieh; Kun Yun Yeh; Eric Yen Chao Chen; Shih Wei Yang; Jen Seng Huang; Chien Hong Lai; Tsung Han Wu; Yen Min Huang; Yueh Shih Chang; Wen Chi Chou; Cheng Hsu Wang

doi:10.6133/apjcn.032018.04

Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer

Pei Hung Chang
, Jason Chia Hsun Hsieh
, Kun Yun Yeh
, Eric Yen Chao Chen
, Shih Wei Yang
, Jen Seng Huang
, Chien Hong Lai
, Tsung Han Wu
, Yen Min Huang
, Yueh Shih Chang
, Wen Chi Chou
, Cheng Hsu Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

Background and Objectives: This study was designed to evaluate the impact of the prognostic nutritional index (PNI) on treatment-related toxicities and tolerance in patients with advanced head and neck cancers who were undergoing concurrent chemoradiotherapy (CCRT). Methods and Study Design: We retrospectively analyzed and compared the clinical characteristic, toxicities and survival of 143 patients with stage III, IVA, and IVB head and neck cancer who were treated with CCRT according to their PNI between 2007 and 2010. Results: Low PNI was correlated with T classification and advanced tumor stage. Patients with low PNI were less likely to tolerate CCRT, required tube feeding support more frequently and had higher percentages of grade 3/4 hematological toxicities, sepsis and toxic death. Conclusions: Pretreatment PNI predicts treatment-tolerance and toxicity in patients with advanced head and neck cancer undergoing CCRT.

Original language	English
Pages (from-to)	996-1001
Number of pages	6
Journal	Asia Pacific Journal of Clinical Nutrition
Volume	27
Issue number	5
DOIs	https://doi.org/10.6133/apjcn.032018.04
State	Published - 01 09 2018

Bibliographical note

Publisher Copyright:
© 2018, HEC Press.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger
SDG 3 Good Health and Well-being

Keywords

Chemoradiotherapy
Head and neck cancer
Malnutrition
Prognostic nutritional index
Toxicities

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10.6133/apjcn.032018.04

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Chang, P. H., Hsieh, J. C. H., Yeh, K. Y., Chen, E. Y. C., Yang, S. W., Huang, J. S., Lai, C. H., Wu, T. H., Huang, Y. M., Chang, Y. S., Chou, W. C., & Wang, C. H. (2018). Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer. Asia Pacific Journal of Clinical Nutrition, 27(5), 996-1001. https://doi.org/10.6133/apjcn.032018.04

@article{6b71a9eda22d408890b17d94689a2e07,

title = "Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer",

abstract = "Background and Objectives: This study was designed to evaluate the impact of the prognostic nutritional index (PNI) on treatment-related toxicities and tolerance in patients with advanced head and neck cancers who were undergoing concurrent chemoradiotherapy (CCRT). Methods and Study Design: We retrospectively analyzed and compared the clinical characteristic, toxicities and survival of 143 patients with stage III, IVA, and IVB head and neck cancer who were treated with CCRT according to their PNI between 2007 and 2010. Results: Low PNI was correlated with T classification and advanced tumor stage. Patients with low PNI were less likely to tolerate CCRT, required tube feeding support more frequently and had higher percentages of grade 3/4 hematological toxicities, sepsis and toxic death. Conclusions: Pretreatment PNI predicts treatment-tolerance and toxicity in patients with advanced head and neck cancer undergoing CCRT.",

keywords = "Chemoradiotherapy, Head and neck cancer, Malnutrition, Prognostic nutritional index, Toxicities",

author = "Chang, \{Pei Hung\} and Hsieh, \{Jason Chia Hsun\} and Yeh, \{Kun Yun\} and Chen, \{Eric Yen Chao\} and Yang, \{Shih Wei\} and Huang, \{Jen Seng\} and Lai, \{Chien Hong\} and Wu, \{Tsung Han\} and Huang, \{Yen Min\} and Chang, \{Yueh Shih\} and Chou, \{Wen Chi\} and Wang, \{Cheng Hsu\}",

note = "Publisher Copyright: {\textcopyright} 2018, HEC Press.",

year = "2018",

month = sep,

day = "1",

doi = "10.6133/apjcn.032018.04",

language = "英语",

volume = "27",

pages = "996--1001",

journal = "Asia Pacific Journal of Clinical Nutrition",

issn = "0964-7058",

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}

Chang, PH, Hsieh, JCH, Yeh, KY, Chen, EYC, Yang, SW, Huang, JS, Lai, CH, Wu, TH, Huang, YM, Chang, YS, Chou, WC & Wang, CH 2018, 'Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer', Asia Pacific Journal of Clinical Nutrition, vol. 27, no. 5, pp. 996-1001. https://doi.org/10.6133/apjcn.032018.04

TY - JOUR

T1 - Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer

AU - Chang, Pei Hung

AU - Hsieh, Jason Chia Hsun

AU - Yeh, Kun Yun

AU - Chen, Eric Yen Chao

AU - Yang, Shih Wei

AU - Huang, Jen Seng

AU - Lai, Chien Hong

AU - Wu, Tsung Han

AU - Huang, Yen Min

AU - Chang, Yueh Shih

AU - Chou, Wen Chi

AU - Wang, Cheng Hsu

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background and Objectives: This study was designed to evaluate the impact of the prognostic nutritional index (PNI) on treatment-related toxicities and tolerance in patients with advanced head and neck cancers who were undergoing concurrent chemoradiotherapy (CCRT). Methods and Study Design: We retrospectively analyzed and compared the clinical characteristic, toxicities and survival of 143 patients with stage III, IVA, and IVB head and neck cancer who were treated with CCRT according to their PNI between 2007 and 2010. Results: Low PNI was correlated with T classification and advanced tumor stage. Patients with low PNI were less likely to tolerate CCRT, required tube feeding support more frequently and had higher percentages of grade 3/4 hematological toxicities, sepsis and toxic death. Conclusions: Pretreatment PNI predicts treatment-tolerance and toxicity in patients with advanced head and neck cancer undergoing CCRT.

AB - Background and Objectives: This study was designed to evaluate the impact of the prognostic nutritional index (PNI) on treatment-related toxicities and tolerance in patients with advanced head and neck cancers who were undergoing concurrent chemoradiotherapy (CCRT). Methods and Study Design: We retrospectively analyzed and compared the clinical characteristic, toxicities and survival of 143 patients with stage III, IVA, and IVB head and neck cancer who were treated with CCRT according to their PNI between 2007 and 2010. Results: Low PNI was correlated with T classification and advanced tumor stage. Patients with low PNI were less likely to tolerate CCRT, required tube feeding support more frequently and had higher percentages of grade 3/4 hematological toxicities, sepsis and toxic death. Conclusions: Pretreatment PNI predicts treatment-tolerance and toxicity in patients with advanced head and neck cancer undergoing CCRT.

KW - Chemoradiotherapy

KW - Head and neck cancer

KW - Malnutrition

KW - Prognostic nutritional index

KW - Toxicities

UR - https://www.scopus.com/pages/publications/85054605931

U2 - 10.6133/apjcn.032018.04

DO - 10.6133/apjcn.032018.04

M3 - 文章

C2 - 30272847

AN - SCOPUS:85054605931

SN - 0964-7058

VL - 27

SP - 996

EP - 1001

JO - Asia Pacific Journal of Clinical Nutrition

JF - Asia Pacific Journal of Clinical Nutrition

IS - 5

ER -

Prognostic nutritional index relevance in chemoradiotherapy for advanced oral cavity, oropharyngeal and hypopharyngeal cancer

Abstract

Bibliographical note

UN SDGs

Keywords

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