Prognostic significance of the number of examined lymph nodes in node-negative gastric adenocarcinoma

J. T. Hsu*, C. J. Lin, C. M. Sung, H. C. Yeh, T. H. Chen, T. C. Chen, K. C. Chiang, T. S. Yeh, T. L. Hwang, Y. Y. Jan

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

33 Scopus citations

Abstract

Aim In this study, we investigated the prognostic significance of the number of examined lymph nodes in node-negative gastric adenocarcinoma (GC). Patients and methods A total of 1194 node-positive and 1030 node-negative GC patients undergoing potentially curative gastrectomy was enrolled in this study. Patients were stratified into 3 groups according to the number of examined lymph nodes: group 1, ≤15; group 2, 16-25; group 3, >25. Results Patients with node-negative GC had significantly favorable survival compared with those with node-positive. Among patients with node-negative T2-T4 disease, the percentage of locoregional relapse was higher in those with <25 examined lymph nodes than in those with ≥25 examined lymph nodes. The number of examined lymph nodes affected the overall survival rates for patients with node-negative T2-T4 GC but not for patients with T1 lesions. Tumor size, tumor location, the number of examined lymph nodes, T status, and the presence of perineural invasion were significant prognostic factors as determined by multivariate analysis in node-negative GC. Conclusions No survival benefit of examining ≥15 lymph nodes was noted for patients with node-negative T1 GC. Extensive lymphadenectomy in patients with node-negative T2-T4 lesions in whom the number of examined lymph nodes was >25 had favorable survival.

Original languageEnglish
Pages (from-to)1287-1293
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume39
Issue number11
DOIs
StatePublished - 11 2013
Externally publishedYes

Keywords

  • Gastric cancer
  • Lymphadenectomy
  • Node-negative
  • Number of examined lymph node
  • Prognostic factor

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