Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

Wan Yu Chen; Chen Tu Wu; Chun Wei Wang; Keng Hsueh Lan; Hsiang Kuang Liang; Bing Shen Huang; Yih Leong Chang; Sung Hsin Kuo; Ann Lii Cheng

doi:10.1186/s13014-018-1099-6

Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

Wan Yu Chen, Chen Tu Wu, Chun Wei Wang, Keng Hsueh Lan, Hsiang Kuang Liang, Bing Shen Huang, Yih Leong Chang^*, Sung Hsin Kuo, Ann Lii Cheng

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

28 Scopus citations

Abstract

Background: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. Methods: The presence of CD3 ⁺ , CD4 ⁺ , CD8 ⁺ , and forkhead box protein P3-positive (FOXP3 ⁺ ) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. Results: The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p=0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p=0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p=0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). Conclusions: In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.

Original language	English
Article number	157
Journal	Radiation Oncology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s13014-018-1099-6
State	Published - 28 08 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

Keywords

Adjuvant
Head neck cancer
Prognosis
Tongue cancer
Tumor-infiltrating lymphocytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{f02a1ab610ea415fa169704d22979835,

title = "Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer",

abstract = " Background: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. Methods: The presence of CD3 + , CD4 + , CD8 + , and forkhead box protein P3-positive (FOXP3 + ) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. Results: The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p=0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p=0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p=0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). Conclusions: In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.",

keywords = "Adjuvant, Head neck cancer, Prognosis, Tongue cancer, Tumor-infiltrating lymphocytes",

author = "Chen, {Wan Yu} and Wu, {Chen Tu} and Wang, {Chun Wei} and Lan, {Keng Hsueh} and Liang, {Hsiang Kuang} and Huang, {Bing Shen} and Chang, {Yih Leong} and Kuo, {Sung Hsin} and Cheng, {Ann Lii}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

month = aug,

day = "28",

doi = "10.1186/s13014-018-1099-6",

language = "英语",

volume = "13",

journal = "Radiation Oncology",

issn = "1748-717X",

publisher = "BioMed Central Ltd",

number = "1",

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TY - JOUR

T1 - Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

AU - Chen, Wan Yu

AU - Wu, Chen Tu

AU - Wang, Chun Wei

AU - Lan, Keng Hsueh

AU - Liang, Hsiang Kuang

AU - Huang, Bing Shen

AU - Chang, Yih Leong

AU - Kuo, Sung Hsin

AU - Cheng, Ann Lii

PY - 2018/8/28

Y1 - 2018/8/28

N2 - Background: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. Methods: The presence of CD3 + , CD4 + , CD8 + , and forkhead box protein P3-positive (FOXP3 + ) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. Results: The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p=0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p=0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p=0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). Conclusions: In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.

AB - Background: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. Methods: The presence of CD3 + , CD4 + , CD8 + , and forkhead box protein P3-positive (FOXP3 + ) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. Results: The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p=0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p=0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p=0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). Conclusions: In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.

KW - Adjuvant

KW - Head neck cancer

KW - Prognosis

KW - Tongue cancer

KW - Tumor-infiltrating lymphocytes

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U2 - 10.1186/s13014-018-1099-6

DO - 10.1186/s13014-018-1099-6

M3 - 文章

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AN - SCOPUS:85052504982

SN - 1748-717X

VL - 13

JO - Radiation Oncology

JF - Radiation Oncology

IS - 1

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ER -

Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

Abstract

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Keywords

UN SDGs

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