Prognostic Utility of Neck Lymph Node-to-Primary Tumor Standardized Uptake Value Ratio in Oral Cavity Cancer

Kuo Wei Ho, Ku Hao Fang, Chang Hsien Lu, Cheng Ming Hsu, Chia Hsuan Lai, Chun Ta Liao, Chung Jan Kang, Yuan Hsiung Tsai, Ming Shao Tsai, Ethan I. Huang, Geng He Chang, Chien An Ko, Ming Hsien Tsai, Yao Te Tsai*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

We investigated the prognostic utility of preoperative neck lymph node-to-primary tumor maximum standardized uptake value ratios (NTRs) in oral cavity squamous cell carcinoma (OSCC). We retrospectively reviewed the medical records of 141 consecutive patients who were diagnosed as having OSCC and had received fluorodeoxyglucose–positron emission tomography within 2 weeks prior to radical surgery between 2009 and 2018. To determine the optimal NTR cutoff, receiver operating characteristic analysis for overall survival (OS) was executed. The NTR’s prognostic value for disease-free survival (DFS) and OS were determined through Cox proportional hazards analysis and the Kaplan–Meier method. We determined the median (range) follow-up duration to be 35.2 (2.1–122.4) months. The optimal NTR cutoff was 0.273, and patients with a higher NTR (≥0.273) exhibited significantly worse DFS and OS (p = 0.010 and 0.003, respectively). A higher NTR (≥0.273) predicted poorer DFS (hazard ratio: 2.696, p = 0.008) and OS (hazard ratio: 4.865, p = 0.003) in multivariable analysis. We created a nomogram on the basis of the NTR, and it could accurately predict OS (concordance index: 0.774). Preoperative NTRs may be a useful prognostic biomarker for DFS and OS in patients with OSCC who have undergone surgery. NTR-based nomograms may also be helpful prognostic tools in clinical trials.

Original languageEnglish
Article number1954
JournalBiomedicines
Volume11
Issue number7
DOIs
StatePublished - 11 07 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • FDG PET
  • biomarker
  • nomogram
  • oral cavity cancer
  • prognosis

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