Prognostic utility of neutrophil-to-albumin ratio in surgically treated oral squamous cell carcinoma

Ya Yun Yu; Yu Tsai Lin; Hui Ching Chuang; Chih Yen Chien; Tai-Lin Huang; Fu-Min Fang; Yao Te Tsai; Hui Lu; Ming Hsien Tsai

doi:10.1002/hed.27511

Prognostic utility of neutrophil-to-albumin ratio in surgically treated oral squamous cell carcinoma

Ya Yun Yu, Yu Tsai Lin, Hui Ching Chuang, Chih Yen Chien, Tai-Lin Huang, Fu-Min Fang, Yao Te Tsai, Hui Lu, Ming Hsien Tsai^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

BACKGROUND: We aimed to evaluate the prognostic significance of preoperative neutrophil-to-albumin ratio (NAR) in oral squamous cell carcinoma (OSCC).

METHODS: A total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome-associated factors.

RESULTS: The optimal cut-off of NAR to predict overall survival (OS) was determined to be 0.1. In Cox model, high NAR was identified as an independent negative prognosticator of OS, cancer-specific survival, and recurrence-free survival (adjusted hazard ratio: 1.503, 1.958, and 1.727, respectively; all p < 0.05). The NAR-based nomogram accurately predicted OS (concordance index: 0.750).

CONCLUSION: Our study suggests that preoperative NAR is a convenient and effective prognostic marker for OSCC and NAR-based nomogram can be a promising prognostic tool in clinical setting.

Original language	English
Pages (from-to)	2839-2850
Number of pages	12
Journal	Head and Neck
Volume	45
Issue number	11
DOIs	https://doi.org/10.1002/hed.27511
State	Published - 11 2023
Externally published	Yes

Bibliographical note

Keywords

absolute neutrophil count
albumin
neutrophil-to-albumin ratio
oral cancer
prognosis
Prognosis
Humans
Carcinoma, Squamous Cell
Albumins
Squamous Cell Carcinoma of Head and Neck/surgery
Mouth Neoplasms/pathology
Neutrophils/pathology
Retrospective Studies
Head and Neck Neoplasms/pathology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.27511

Cite this

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title = "Prognostic utility of neutrophil-to-albumin ratio in surgically treated oral squamous cell carcinoma",

abstract = "BACKGROUND: We aimed to evaluate the prognostic significance of preoperative neutrophil-to-albumin ratio (NAR) in oral squamous cell carcinoma (OSCC).METHODS: A total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome-associated factors.RESULTS: The optimal cut-off of NAR to predict overall survival (OS) was determined to be 0.1. In Cox model, high NAR was identified as an independent negative prognosticator of OS, cancer-specific survival, and recurrence-free survival (adjusted hazard ratio: 1.503, 1.958, and 1.727, respectively; all p < 0.05). The NAR-based nomogram accurately predicted OS (concordance index: 0.750).CONCLUSION: Our study suggests that preoperative NAR is a convenient and effective prognostic marker for OSCC and NAR-based nomogram can be a promising prognostic tool in clinical setting.",

keywords = "absolute neutrophil count, albumin, neutrophil-to-albumin ratio, oral cancer, prognosis, Prognosis, Humans, Carcinoma, Squamous Cell, Albumins, Squamous Cell Carcinoma of Head and Neck/surgery, Mouth Neoplasms/pathology, Neutrophils/pathology, Retrospective Studies, Head and Neck Neoplasms/pathology",

author = "Yu, \{Ya Yun\} and Lin, \{Yu Tsai\} and Chuang, \{Hui Ching\} and Chien, \{Chih Yen\} and Tai-Lin Huang and Fu-Min Fang and Tsai, \{Yao Te\} and Hui Lu and Tsai, \{Ming Hsien\}",

note = "{\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = nov,

doi = "10.1002/hed.27511",

language = "英语",

volume = "45",

pages = "2839--2850",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "11",

}

TY - JOUR

T1 - Prognostic utility of neutrophil-to-albumin ratio in surgically treated oral squamous cell carcinoma

AU - Yu, Ya Yun

AU - Lin, Yu Tsai

AU - Chuang, Hui Ching

AU - Chien, Chih Yen

AU - Huang, Tai-Lin

AU - Fang, Fu-Min

AU - Tsai, Yao Te

AU - Lu, Hui

AU - Tsai, Ming Hsien

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: We aimed to evaluate the prognostic significance of preoperative neutrophil-to-albumin ratio (NAR) in oral squamous cell carcinoma (OSCC).METHODS: A total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome-associated factors.RESULTS: The optimal cut-off of NAR to predict overall survival (OS) was determined to be 0.1. In Cox model, high NAR was identified as an independent negative prognosticator of OS, cancer-specific survival, and recurrence-free survival (adjusted hazard ratio: 1.503, 1.958, and 1.727, respectively; all p < 0.05). The NAR-based nomogram accurately predicted OS (concordance index: 0.750).CONCLUSION: Our study suggests that preoperative NAR is a convenient and effective prognostic marker for OSCC and NAR-based nomogram can be a promising prognostic tool in clinical setting.

AB - BACKGROUND: We aimed to evaluate the prognostic significance of preoperative neutrophil-to-albumin ratio (NAR) in oral squamous cell carcinoma (OSCC).METHODS: A total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome-associated factors.RESULTS: The optimal cut-off of NAR to predict overall survival (OS) was determined to be 0.1. In Cox model, high NAR was identified as an independent negative prognosticator of OS, cancer-specific survival, and recurrence-free survival (adjusted hazard ratio: 1.503, 1.958, and 1.727, respectively; all p < 0.05). The NAR-based nomogram accurately predicted OS (concordance index: 0.750).CONCLUSION: Our study suggests that preoperative NAR is a convenient and effective prognostic marker for OSCC and NAR-based nomogram can be a promising prognostic tool in clinical setting.

KW - absolute neutrophil count

KW - albumin

KW - neutrophil-to-albumin ratio

KW - oral cancer

KW - prognosis

KW - Prognosis

KW - Humans

KW - Carcinoma, Squamous Cell

KW - Albumins

KW - Squamous Cell Carcinoma of Head and Neck/surgery

KW - Mouth Neoplasms/pathology

KW - Neutrophils/pathology

KW - Retrospective Studies

KW - Head and Neck Neoplasms/pathology

UR - https://www.scopus.com/pages/publications/85170692262

U2 - 10.1002/hed.27511

DO - 10.1002/hed.27511

M3 - 文章

C2 - 37698535

AN - SCOPUS:85170692262

SN - 1043-3074

VL - 45

SP - 2839

EP - 2850

JO - Head and Neck

JF - Head and Neck

IS - 11

ER -

Prognostic utility of neutrophil-to-albumin ratio in surgically treated oral squamous cell carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

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