Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis

Yao Te Tsai; Liang Tseng Kuo; Yun Ting Wang; Andrea De Vito; Sheng Po Hao; Ku Hao Fang; Yi Chan Lee; Kuan Yin Chen; Chia Hsuan Lai; Yuan Hsiung Tsai; Ethan I. Huang; Ming Shao Tsai; Cheng Ming Hsu; Geng He Chang; Chih Wei Luan

doi:10.1002/hed.27842

Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis

Yao Te Tsai
, Liang Tseng Kuo
, Yun Ting Wang
, Andrea De Vito
, Sheng Po Hao
, Ku Hao Fang
, Yi Chan Lee
, Kuan Yin Chen
, Chia Hsuan Lai
, Yuan Hsiung Tsai
, Ethan I. Huang
, Ming Shao Tsai
, Cheng Ming Hsu
, Geng He Chang
, Chih Wei Luan^*

^*Corresponding author for this work

School of Medicine

Chang Gung Memorial Hospital
Chang Gung University
Forlì Hospital Health Local Agency of Romagna
Shin Kong Wu Ho-Su Memorial Hospital
National Yang Ming Chiao Tung University
Lunghwa University of Science and Technology
Lo Sheng Sanatorium and Hospital Ministry of Health and Welfare

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.

Original language	English
Pages (from-to)	2086-2097
Number of pages	12
Journal	Head and Neck
Volume	46
Issue number	8
DOIs	https://doi.org/10.1002/hed.27842
State	Published - 08 2024

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger
SDG 3 Good Health and Well-being

Keywords

geriatric nutritional risk index
head and neck cancer
meta-analysis
prognosis
systematic review
Head and Neck Neoplasms/mortality
Prognosis
Risk Assessment
Humans
Nutrition Assessment
Geriatric Assessment/methods
Aged
Nutritional Status

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10.1002/hed.27842

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Tsai, Y. T., Kuo, L. T., Wang, Y. T., De Vito, A., Hao, S. P., Fang, K. H., Lee, Y. C., Chen, K. Y., Lai, C. H., Tsai, Y. H., Huang, E. I., Tsai, M. S., Hsu, C. M., Chang, G. H., & Luan, C. W. (2024). Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis. Head and Neck, 46(8), 2086-2097. https://doi.org/10.1002/hed.27842

@article{743823a9bdba45fb924700b7de2c468f,

title = "Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis",

abstract = "We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95\% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95\% CI = 1.32{\textendash}2.65, p < 0.001) and overall survival (HR = 3.04, 95\% CI = 2.30{\textendash}4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.",

keywords = "geriatric nutritional risk index, head and neck cancer, meta-analysis, prognosis, systematic review, Head and Neck Neoplasms/mortality, Prognosis, Risk Assessment, Humans, Nutrition Assessment, Geriatric Assessment/methods, Aged, Nutritional Status",

author = "Tsai, \{Yao Te\} and Kuo, \{Liang Tseng\} and Wang, \{Yun Ting\} and \{De Vito\}, Andrea and Hao, \{Sheng Po\} and Fang, \{Ku Hao\} and Lee, \{Yi Chan\} and Chen, \{Kuan Yin\} and Lai, \{Chia Hsuan\} and Tsai, \{Yuan Hsiung\} and Huang, \{Ethan I.\} and Tsai, \{Ming Shao\} and Hsu, \{Cheng Ming\} and Chang, \{Geng He\} and Luan, \{Chih Wei\}",

note = "{\textcopyright} 2024 Wiley Periodicals LLC.",

year = "2024",

month = aug,

doi = "10.1002/hed.27842",

language = "英语",

volume = "46",

pages = "2086--2097",

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T1 - Prognostic utility of the geriatric nutritional risk index for head and neck cancer

T2 - Systematic review and meta-analysis

AU - Tsai, Yao Te

AU - Kuo, Liang Tseng

AU - Wang, Yun Ting

AU - De Vito, Andrea

AU - Hao, Sheng Po

AU - Fang, Ku Hao

AU - Lee, Yi Chan

AU - Chen, Kuan Yin

AU - Lai, Chia Hsuan

AU - Tsai, Yuan Hsiung

AU - Huang, Ethan I.

AU - Tsai, Ming Shao

AU - Hsu, Cheng Ming

AU - Chang, Geng He

AU - Luan, Chih Wei

PY - 2024/8

Y1 - 2024/8

N2 - We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.

AB - We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.

KW - geriatric nutritional risk index

KW - head and neck cancer

KW - meta-analysis

KW - prognosis

KW - systematic review

KW - Head and Neck Neoplasms/mortality

KW - Prognosis

KW - Risk Assessment

KW - Humans

KW - Nutrition Assessment

KW - Geriatric Assessment/methods

KW - Aged

KW - Nutritional Status

UR - https://www.scopus.com/pages/publications/85195504020

U2 - 10.1002/hed.27842

DO - 10.1002/hed.27842

M3 - 文献综述

C2 - 38853422

AN - SCOPUS:85195504020

SN - 1043-3074

VL - 46

SP - 2086

EP - 2097

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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