Prognostic value of pretreatment 18F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma

Nai Ming Cheng; Joseph Tung Chieh Chang; Chung Guei Huang; Din Li Tsan; Shu Hang Ng; Hung Ming Wang; Chun Ta Liao; Chien Yu Lin; Cheng Lung Hsu; Tzu Chen Yen

doi:10.1007/s00259-012-2186-9

Prognostic value of pretreatment ¹⁸F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma

Nai Ming Cheng
, Joseph Tung Chieh Chang
, Chung Guei Huang
, Din Li Tsan
, Shu Hang Ng
, Hung Ming Wang
, Chun Ta Liao
, Chien Yu Lin
, Cheng Lung Hsu
, Tzu Chen Yen^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

45 Scopus citations

Abstract

Purpose Human papillomavirus type 16 (HPV-16) positivity is associated with favourable survival in oropharyngeal squamous cell carcinoma (OPSCC). We report here a study of the prognostic significance of ¹⁸F-FDG PET/CT functional parameters and HPV-16 infection in OPSCC patients. Methods We retrospectively analysed 60 patients with stage III or IV OPSCC who had had a pretherapy ¹⁸F-FDG PET/ CT scan and had completed concurrent chemoradiotherapy (n058) or curative radiotherapy (n02). All patients were followed up for ≥24 months or until death. We determined total lesion glycolysis (TLG) and the maximal standardized uptake values (SUV_max) of the primary tumour and neck lymph nodes from the pretherapy ¹⁸F-FDG PET/CT scan. Optimal cut-offs of the ¹⁸F-FDG PET/CT parameters were obtained by receiver operating characteristic (ROC) curve analyses. Pretherapy tumour biopsies were studied by polymerase chain reaction to determine HPV infection status. Results The pretherapy tumour biopsies were positive for HPV-16 in 12 patients (20.0 %). Cox regression analyses revealed HPV-16 positivity and tumour TLG >135.3 g to be independently associated with overall survival (p0 0.027 and 0.011, respectively). However, only tumour TLG >135.3 g was independently associated with progression-free survival, disease-free survival and locoregional control (p00.011, 0.001 and 0.034, respectively). A scoring system was formulated to define distinct overall survival groups using tumour TLG and HPV-16 status. Patients positive for HPV-16 and with tumour TLG ≤135.3 g experienced better survival than those with tumour TLG >135.3 g and no HPV infection (p00.001). Conclusion Tumour TLG was an independent predictor of survival in patients with locally advanced OPSCC. A scoring system was developed and may serve as a risk stratification strategy for guiding therapy.

Original language	English
Pages (from-to)	1673-1684
Number of pages	12
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	39
Issue number	11
DOIs	https://doi.org/10.1007/s00259-012-2186-9
State	Published - 11 2012

Keywords

FDG
HPV
Head and neck
Keywords Oropharyngeal carcinoma
PET/CT
Prognosis
Standardized uptake value
Total lesion glycolysis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00259-012-2186-9

Cite this

Cheng, N. M., Chang, J. T. C., Huang, C. G., Tsan, D. L., Ng, S. H., Wang, H. M., Liao, C. T., Lin, C. Y., Hsu, C. L., & Yen, T. C. (2012). Prognostic value of pretreatment ¹⁸F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma. European Journal of Nuclear Medicine and Molecular Imaging, 39(11), 1673-1684. https://doi.org/10.1007/s00259-012-2186-9

@article{5d2dd65e0c6c4f288a23f6f576a940b1,

title = "Prognostic value of pretreatment 18F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma",

abstract = "Purpose Human papillomavirus type 16 (HPV-16) positivity is associated with favourable survival in oropharyngeal squamous cell carcinoma (OPSCC). We report here a study of the prognostic significance of 18F-FDG PET/CT functional parameters and HPV-16 infection in OPSCC patients. Methods We retrospectively analysed 60 patients with stage III or IV OPSCC who had had a pretherapy 18F-FDG PET/ CT scan and had completed concurrent chemoradiotherapy (n058) or curative radiotherapy (n02). All patients were followed up for ≥24 months or until death. We determined total lesion glycolysis (TLG) and the maximal standardized uptake values (SUVmax) of the primary tumour and neck lymph nodes from the pretherapy 18F-FDG PET/CT scan. Optimal cut-offs of the 18F-FDG PET/CT parameters were obtained by receiver operating characteristic (ROC) curve analyses. Pretherapy tumour biopsies were studied by polymerase chain reaction to determine HPV infection status. Results The pretherapy tumour biopsies were positive for HPV-16 in 12 patients (20.0 \%). Cox regression analyses revealed HPV-16 positivity and tumour TLG >135.3 g to be independently associated with overall survival (p0 0.027 and 0.011, respectively). However, only tumour TLG >135.3 g was independently associated with progression-free survival, disease-free survival and locoregional control (p00.011, 0.001 and 0.034, respectively). A scoring system was formulated to define distinct overall survival groups using tumour TLG and HPV-16 status. Patients positive for HPV-16 and with tumour TLG ≤135.3 g experienced better survival than those with tumour TLG >135.3 g and no HPV infection (p00.001). Conclusion Tumour TLG was an independent predictor of survival in patients with locally advanced OPSCC. A scoring system was developed and may serve as a risk stratification strategy for guiding therapy.",

keywords = "FDG, HPV, Head and neck, Keywords Oropharyngeal carcinoma, PET/CT, Prognosis, Standardized uptake value, Total lesion glycolysis",

author = "Cheng, \{Nai Ming\} and Chang, \{Joseph Tung Chieh\} and Huang, \{Chung Guei\} and Tsan, \{Din Li\} and Ng, \{Shu Hang\} and Wang, \{Hung Ming\} and Liao, \{Chun Ta\} and Lin, \{Chien Yu\} and Hsu, \{Cheng Lung\} and Yen, \{Tzu Chen\}",

year = "2012",

month = nov,

doi = "10.1007/s00259-012-2186-9",

language = "英语",

volume = "39",

pages = "1673--1684",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer",

number = "11",

}

Cheng, NM, Chang, JTC, Huang, CG, Tsan, DL, Ng, SH, Wang, HM, Liao, CT, Lin, CY, Hsu, CL & Yen, TC 2012, 'Prognostic value of pretreatment ¹⁸F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma', European Journal of Nuclear Medicine and Molecular Imaging, vol. 39, no. 11, pp. 1673-1684. https://doi.org/10.1007/s00259-012-2186-9

Prognostic value of pretreatment ¹⁸F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma. / Cheng, Nai Ming; Chang, Joseph Tung Chieh; Huang, Chung Guei et al.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, No. 11, 11.2012, p. 1673-1684.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Prognostic value of pretreatment 18F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma

AU - Cheng, Nai Ming

AU - Chang, Joseph Tung Chieh

AU - Huang, Chung Guei

AU - Tsan, Din Li

AU - Ng, Shu Hang

AU - Wang, Hung Ming

AU - Liao, Chun Ta

AU - Lin, Chien Yu

AU - Hsu, Cheng Lung

AU - Yen, Tzu Chen

PY - 2012/11

Y1 - 2012/11

N2 - Purpose Human papillomavirus type 16 (HPV-16) positivity is associated with favourable survival in oropharyngeal squamous cell carcinoma (OPSCC). We report here a study of the prognostic significance of 18F-FDG PET/CT functional parameters and HPV-16 infection in OPSCC patients. Methods We retrospectively analysed 60 patients with stage III or IV OPSCC who had had a pretherapy 18F-FDG PET/ CT scan and had completed concurrent chemoradiotherapy (n058) or curative radiotherapy (n02). All patients were followed up for ≥24 months or until death. We determined total lesion glycolysis (TLG) and the maximal standardized uptake values (SUVmax) of the primary tumour and neck lymph nodes from the pretherapy 18F-FDG PET/CT scan. Optimal cut-offs of the 18F-FDG PET/CT parameters were obtained by receiver operating characteristic (ROC) curve analyses. Pretherapy tumour biopsies were studied by polymerase chain reaction to determine HPV infection status. Results The pretherapy tumour biopsies were positive for HPV-16 in 12 patients (20.0 %). Cox regression analyses revealed HPV-16 positivity and tumour TLG >135.3 g to be independently associated with overall survival (p0 0.027 and 0.011, respectively). However, only tumour TLG >135.3 g was independently associated with progression-free survival, disease-free survival and locoregional control (p00.011, 0.001 and 0.034, respectively). A scoring system was formulated to define distinct overall survival groups using tumour TLG and HPV-16 status. Patients positive for HPV-16 and with tumour TLG ≤135.3 g experienced better survival than those with tumour TLG >135.3 g and no HPV infection (p00.001). Conclusion Tumour TLG was an independent predictor of survival in patients with locally advanced OPSCC. A scoring system was developed and may serve as a risk stratification strategy for guiding therapy.

AB - Purpose Human papillomavirus type 16 (HPV-16) positivity is associated with favourable survival in oropharyngeal squamous cell carcinoma (OPSCC). We report here a study of the prognostic significance of 18F-FDG PET/CT functional parameters and HPV-16 infection in OPSCC patients. Methods We retrospectively analysed 60 patients with stage III or IV OPSCC who had had a pretherapy 18F-FDG PET/ CT scan and had completed concurrent chemoradiotherapy (n058) or curative radiotherapy (n02). All patients were followed up for ≥24 months or until death. We determined total lesion glycolysis (TLG) and the maximal standardized uptake values (SUVmax) of the primary tumour and neck lymph nodes from the pretherapy 18F-FDG PET/CT scan. Optimal cut-offs of the 18F-FDG PET/CT parameters were obtained by receiver operating characteristic (ROC) curve analyses. Pretherapy tumour biopsies were studied by polymerase chain reaction to determine HPV infection status. Results The pretherapy tumour biopsies were positive for HPV-16 in 12 patients (20.0 %). Cox regression analyses revealed HPV-16 positivity and tumour TLG >135.3 g to be independently associated with overall survival (p0 0.027 and 0.011, respectively). However, only tumour TLG >135.3 g was independently associated with progression-free survival, disease-free survival and locoregional control (p00.011, 0.001 and 0.034, respectively). A scoring system was formulated to define distinct overall survival groups using tumour TLG and HPV-16 status. Patients positive for HPV-16 and with tumour TLG ≤135.3 g experienced better survival than those with tumour TLG >135.3 g and no HPV infection (p00.001). Conclusion Tumour TLG was an independent predictor of survival in patients with locally advanced OPSCC. A scoring system was developed and may serve as a risk stratification strategy for guiding therapy.

KW - FDG

KW - HPV

KW - Head and neck

KW - Keywords Oropharyngeal carcinoma

KW - PET/CT

KW - Prognosis

KW - Standardized uptake value

KW - Total lesion glycolysis

UR - https://www.scopus.com/pages/publications/84868195526

U2 - 10.1007/s00259-012-2186-9

DO - 10.1007/s00259-012-2186-9

M3 - 文章

C2 - 22854984

AN - SCOPUS:84868195526

SN - 1619-7070

VL - 39

SP - 1673

EP - 1684

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 11

ER -