Prolonged QT interval is linked to all-cause and cardiac mortality in chronic peritoneal dialysis patients

Huey Liang Kuo, Yao Lung Liu, Chih Chia Liang, Chiz Tzung Chang, Su Ming Wang, Jiung Hsiun Liu, Hsin Hung Lin, I. Kuan Wang, Ya Fei Yang, Che Yi Chou*, Chiu Ching Huang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations

Abstract

Aim: Prolonged QT interval is related to changes of electrolytes in haemodialysis (HD) and is associated with all-cause mortality in HD patients. It is unknown if prolonged QT interval is associated with all-cause mortality in peritoneal dialysis (PD) patients as the electrolytes were relatively stable in PD. We therefore investigated the association of prolonged QT interval and all-cause mortality in chronic PD patients. Methods: The QT intervals were measured in 2003 and all patients were followed to December 2012. A prolonged QT interval was defined as a QT interval > 450 ms. The association of prolonged QT interval with all-cause and cardiac-specific mortality was analyzed using Cox regression and Kaplan–Meier analysis. Results: Of 306 patients, 196 (64%) patients had prolonged QT interval. The incidence density rate was 9.7 per 100 persons-years for all-cause mortality and 5.6 for cardiac specific mortality in patients with prolonged QT interval. Prolonged QT interval was associated with all-cause mortality with a hazard ratio (HR) of 1.59 (95% confidence interval (CI): 1.06–2.39, P = 0.03] and cardiac mortality (HR: 1.66, 95% CI: 1.00–2.78, P = 0.05) with adjustments for age, gender, diabetes, and vintage of dialysis. Longer QT interval (>500 ms, 450–500 ms, and < 450 ms) was significantly associated with a worse overall survival (P = 0.03, log-rank test) and cardiac mortality free survival (P = 0.05, log-rank test). Conclusions: Prolonged QT interval was associated with all-cause and cardiac mortality in patients on peritoneal dialysis. The association is independent of patient's age and diabetes.

Original languageEnglish
Pages (from-to)436-440
Number of pages5
JournalNephrology
Volume22
Issue number6
DOIs
StatePublished - 06 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Asian Pacific Society of Nephrology

Keywords

  • QT interval
  • cardiac mortality
  • mortality
  • peritoneal dialysis

Fingerprint

Dive into the research topics of 'Prolonged QT interval is linked to all-cause and cardiac mortality in chronic peritoneal dialysis patients'. Together they form a unique fingerprint.

Cite this