Properties of vitamin E-deficient erythrocytes following peroxidant injury

Bertram Lubin, Danny Chiu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

35 Scopus citations

Abstract

Several membrane properties of vitamin E-deficient and normal erythrocytes were studied after incubation of these cells with hydrogen peroxide. Measurements of mean corpuscular volume, cation permeability, membrane Na+, K+ ATPase activity, red cell filterability through 5 ju millipore filters, and membrane protein pattern on sodium dodecyle sulfate-gel electrophoresis revealed marked alterations before lysis. Vitamin E sufficient cells were unaffected by a similar incubation with hydrogen peroxide. We speculate that the changes in membrane function, which follow peroxidant injury, contribute to the shortened red cell survival in the vitamin E deficient state.

Original languageEnglish
Pages (from-to)928-932
Number of pages5
JournalPediatric Research
Volume16
Issue number11
DOIs
StatePublished - 11 1982
Externally publishedYes

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