Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice

Tse Hung Huang, Yi Han Chiu, Yi Lin Chan, Ya Huang Chiu, Hang Wang, Kuo Chin Huang, Tsung Lin Li, Kuang Hung Hsu*, Chang Jer Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

85 Scopus citations

Abstract

Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC) cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and vascular endothelial growth factor (VEGF). Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs.

Original languageEnglish
Pages (from-to)1882-1900
Number of pages19
JournalMarine Drugs
Volume13
Issue number4
DOIs
StatePublished - 01 04 2015

Bibliographical note

Publisher Copyright:
© 2015 by the authors.

Keywords

  • Cachexia chemo-preventative agent
  • Fucoidan
  • Lung carcinoma
  • Metastasis
  • Sulfated polysaccharide

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