Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes

You Cheng Hseu, Weng Cheng Chang, Yi Ting Hseu, Chia Ying Lee, Yi Jen Yech, Pei Chun Chen, Jing Yi Chen, Hsin Ling Yang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

122 Scopus citations

Abstract

Antrodia camphorata (A. camphorata) is well known in Taiwan as a traditional Chinese medicine. The purpose of this study was to evaluate the ability of aqueous extract from A. camphorata mycelia to protect normal human erythrocytes against oxidative damage in vitro. Oxidative hemolysis and lipid/protein peroxidation of erythrocytes induced by the aqueous peroxyl radical [2,2′-Azobis(2-amidinopropane) dihydrochloride, AAPH] were suppressed by A. camphorata mycelia in a time-and concentration-dependent manner. A. camphorata mycelia also prevented the depletion of cytosolic antioxidant glutathione (GSH) and ATP in erythrocytes. Moreover, cultured human endothelial cell damage induced by AAPH was suppressed by A. camphorata mycelia. Interestingly, A. camphorata mycelia exhibited significant cytotoxicity against leukemia HL-60 cells but not against cultured human endothelial cells. These results imply that A. camphorata mycelia may have protective antioxidant and anticancer properties.

Original languageEnglish
Pages (from-to)469-482
Number of pages14
JournalLife Sciences
Volume71
Issue number4
DOIs
StatePublished - 14 06 2002
Externally publishedYes

Keywords

  • ATP
  • Antioxidants
  • Antrodia Camphorata mycelia
  • Endothelial cells
  • Erythrocyte
  • Glutathione
  • HL-60 cells
  • Hemolysis

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