Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil: Relation to induction of HSP70

X. H. Liu; K. Abe; M. Aoki; T. H. Lee; H. Kato; K. Kogure

doi:10.1016/0024-3205(93)90663-N

Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil: Relation to induction of HSP70

X. H. Liu^*, K. Abe, M. Aoki, T. H. Lee, H. Kato, K. Kogure

^*Corresponding author for this work

Tohoku University

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p<0.05 and p<0.01, respectively) at 7 days after ischemia. Immunohistochemistry against HSP70 protein and in situ hybridization for the mRNA revealed that the inductions of immunoreactive HSP70 and the mRNA were remarkably reduced and limited in the brain hippocampi treated with BF (30 mg/kg) as compared with vehicle-treated animals. These data indicate that BF possesses a protective effect against ischemic injury to the vulnerable CA1 neurons. The possible mechanisms of the protection are discussed.

Original language	English
Pages (from-to)	161-167
Number of pages	7
Journal	Life Sciences
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(93)90663-N
State	Published - 1993
Externally published	Yes

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title = "Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil: Relation to induction of HSP70",

abstract = "A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p<0.05 and p<0.01, respectively) at 7 days after ischemia. Immunohistochemistry against HSP70 protein and in situ hybridization for the mRNA revealed that the inductions of immunoreactive HSP70 and the mRNA were remarkably reduced and limited in the brain hippocampi treated with BF (30 mg/kg) as compared with vehicle-treated animals. These data indicate that BF possesses a protective effect against ischemic injury to the vulnerable CA1 neurons. The possible mechanisms of the protection are discussed.",

author = "Liu, {X. H.} and K. Abe and M. Aoki and Lee, {T. H.} and H. Kato and K. Kogure",

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T1 - Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil

T2 - Relation to induction of HSP70

AU - Liu, X. H.

AU - Abe, K.

AU - Aoki, M.

AU - Lee, T. H.

AU - Kato, H.

AU - Kogure, K.

PY - 1993

Y1 - 1993

N2 - A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p<0.05 and p<0.01, respectively) at 7 days after ischemia. Immunohistochemistry against HSP70 protein and in situ hybridization for the mRNA revealed that the inductions of immunoreactive HSP70 and the mRNA were remarkably reduced and limited in the brain hippocampi treated with BF (30 mg/kg) as compared with vehicle-treated animals. These data indicate that BF possesses a protective effect against ischemic injury to the vulnerable CA1 neurons. The possible mechanisms of the protection are discussed.

AB - A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p<0.05 and p<0.01, respectively) at 7 days after ischemia. Immunohistochemistry against HSP70 protein and in situ hybridization for the mRNA revealed that the inductions of immunoreactive HSP70 and the mRNA were remarkably reduced and limited in the brain hippocampi treated with BF (30 mg/kg) as compared with vehicle-treated animals. These data indicate that BF possesses a protective effect against ischemic injury to the vulnerable CA1 neurons. The possible mechanisms of the protection are discussed.

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DO - 10.1016/0024-3205(93)90663-N

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Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil: Relation to induction of HSP70

Abstract

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