Proton FLASH Irradiation Platform for Small Animal Setup at Chang Gung Memorial Hospital

Tung Yuan Hsiao; Lu Kai Wang; Tzung Yuang Chen; Ching Fang Yu; Cheng Ya Pan; Chun Chieh Wang; Chien Yu Lin; I-Chun Cho; Fang Hsin Chen; Huan Niu; Chien Hsu Chen

doi:10.1109/TRPMS.2023.3319954

Proton FLASH Irradiation Platform for Small Animal Setup at Chang Gung Memorial Hospital

Tung Yuan Hsiao, Lu Kai Wang, Tzung Yuang Chen, Ching Fang Yu, Cheng Ya Pan, Chun Chieh Wang, Chien Yu Lin, I-Chun Cho, Fang Hsin Chen, Huan Niu, Chien Hsu Chen^*

^*Corresponding author for this work

Research Center for Radiation Medicine

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

The purpose of this study was to create a platform for conducting small animal proton FLASH irradiation at a research-specific therapy center using an auxiliary proton beam line. A dose monitoring system was implemented to provide real-time irradiation dose and dose rate time structure information, utilizing a transmission ionization chamber (TIC), a plastic scintillator-based beam position monitor, and a poor man faraday cup (PMFC). Both the TIC and PMFC were equipped with a custom-made fast-reading current integral electronics device, allowing for real-time dose monitoring with a resolution of 0.5 ms. Experimental testing showed that the maximum dose that could be delivered to the target in a single pulse of 230-MeV protons was approximately 20 Gy, during a pulse period of 199 ms, at a dose rate of 100 Gy/s. The establishment of a dedicated proton research platform at Chang Gung Memorial Hospital has enabled investigation of the biological effects of FLASH irradiation on small animals. The final setup data serves as a useful reference for both planning future experiments and improving the facility for beam users. This study's achievement provides a valuable foundation for further research on proton FLASH irradiation, potentially offering new insights into its applications for cancer treatment.

Original language	English
Pages (from-to)	88-94
Number of pages	7
Journal	IEEE Transactions on Radiation and Plasma Medical Sciences
Volume	8
Issue number	1
DOIs	https://doi.org/10.1109/TRPMS.2023.3319954
State	Published - 01 01 2024

Bibliographical note

Publisher Copyright:
© 2017 IEEE.

Keywords

Proton therapy
radiation dosage
radiation monitoring
radiation therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TRPMS.2023.3319954

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title = "Proton FLASH Irradiation Platform for Small Animal Setup at Chang Gung Memorial Hospital",

abstract = "The purpose of this study was to create a platform for conducting small animal proton FLASH irradiation at a research-specific therapy center using an auxiliary proton beam line. A dose monitoring system was implemented to provide real-time irradiation dose and dose rate time structure information, utilizing a transmission ionization chamber (TIC), a plastic scintillator-based beam position monitor, and a poor man faraday cup (PMFC). Both the TIC and PMFC were equipped with a custom-made fast-reading current integral electronics device, allowing for real-time dose monitoring with a resolution of 0.5 ms. Experimental testing showed that the maximum dose that could be delivered to the target in a single pulse of 230-MeV protons was approximately 20 Gy, during a pulse period of 199 ms, at a dose rate of 100 Gy/s. The establishment of a dedicated proton research platform at Chang Gung Memorial Hospital has enabled investigation of the biological effects of FLASH irradiation on small animals. The final setup data serves as a useful reference for both planning future experiments and improving the facility for beam users. This study's achievement provides a valuable foundation for further research on proton FLASH irradiation, potentially offering new insights into its applications for cancer treatment.",

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AU - Pan, Cheng Ya

AU - Wang, Chun Chieh

AU - Lin, Chien Yu

AU - Cho, I-Chun

AU - Chen, Fang Hsin

AU - Niu, Huan

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AB - The purpose of this study was to create a platform for conducting small animal proton FLASH irradiation at a research-specific therapy center using an auxiliary proton beam line. A dose monitoring system was implemented to provide real-time irradiation dose and dose rate time structure information, utilizing a transmission ionization chamber (TIC), a plastic scintillator-based beam position monitor, and a poor man faraday cup (PMFC). Both the TIC and PMFC were equipped with a custom-made fast-reading current integral electronics device, allowing for real-time dose monitoring with a resolution of 0.5 ms. Experimental testing showed that the maximum dose that could be delivered to the target in a single pulse of 230-MeV protons was approximately 20 Gy, during a pulse period of 199 ms, at a dose rate of 100 Gy/s. The establishment of a dedicated proton research platform at Chang Gung Memorial Hospital has enabled investigation of the biological effects of FLASH irradiation on small animals. The final setup data serves as a useful reference for both planning future experiments and improving the facility for beam users. This study's achievement provides a valuable foundation for further research on proton FLASH irradiation, potentially offering new insights into its applications for cancer treatment.

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Proton FLASH Irradiation Platform for Small Animal Setup at Chang Gung Memorial Hospital

Abstract

Bibliographical note

Keywords

UN SDGs

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