Pseudoalteromone A: A novel bioactive ubiquinone from a marine bacterium Pseudoalteromonas sp. CGH2XX (Pseudoalteromonadaceae)

Yu Hsin Chen; Mei Chin Lu; Yu Chia Chang; Tsong Long Hwang; Wei Hsien Wang; Ching Feng Weng; Jimmy Kuo; Ping Jyun Sung

doi:10.1016/j.tetlet.2012.01.104

Pseudoalteromone A: A novel bioactive ubiquinone from a marine bacterium Pseudoalteromonas sp. CGH2XX (Pseudoalteromonadaceae)

Yu Hsin Chen, Mei Chin Lu, Yu Chia Chang, Tsong Long Hwang, Wei Hsien Wang, Ching Feng Weng, Jimmy Kuo^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

A novel ubiquinone derivative, pseudoalteromone A (1), possessing a 9C nor-monoterpenoid moiety was produced from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium is originally isolated from a cultured-type octocoral Lobophytum crassum. The structure of ubiquinone 1 was established by spectroscopic methods. Pseudoalteromone A (1) exhibited significant cytotoxicity toward the MOLT-4 (human acute lymphoblastic leukemia, IC ₅₀ = 3.764 μg/mL) cells and displayed a significant inhibitory effect (inhibition rate 45.1%) on the release of elastase by human neutrophils at a concentration of 10 μg/mL.

Original language	English
Pages (from-to)	1675-1677
Number of pages	3
Journal	Tetrahedron Letters
Volume	53
Issue number	13
DOIs	https://doi.org/10.1016/j.tetlet.2012.01.104
State	Published - 28 03 2012

Keywords

Cytotoxicity
Elastase
Lobophytum
Pseudoalteromonas
Pseudoalteromone
Ubiquinone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tetlet.2012.01.104

Cite this

@article{d26dde5a1a914a24b259be2163820624,

title = "Pseudoalteromone A: A novel bioactive ubiquinone from a marine bacterium Pseudoalteromonas sp. CGH2XX (Pseudoalteromonadaceae)",

abstract = "A novel ubiquinone derivative, pseudoalteromone A (1), possessing a 9C nor-monoterpenoid moiety was produced from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium is originally isolated from a cultured-type octocoral Lobophytum crassum. The structure of ubiquinone 1 was established by spectroscopic methods. Pseudoalteromone A (1) exhibited significant cytotoxicity toward the MOLT-4 (human acute lymphoblastic leukemia, IC 50 = 3.764 μg/mL) cells and displayed a significant inhibitory effect (inhibition rate 45.1%) on the release of elastase by human neutrophils at a concentration of 10 μg/mL.",

keywords = "Cytotoxicity, Elastase, Lobophytum, Pseudoalteromonas, Pseudoalteromone, Ubiquinone",

author = "Chen, {Yu Hsin} and Lu, {Mei Chin} and Chang, {Yu Chia} and Hwang, {Tsong Long} and Wang, {Wei Hsien} and Weng, {Ching Feng} and Jimmy Kuo and Sung, {Ping Jyun}",

year = "2012",

month = mar,

day = "28",

doi = "10.1016/j.tetlet.2012.01.104",

language = "英语",

volume = "53",

pages = "1675--1677",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "13",

}

TY - JOUR

T1 - Pseudoalteromone A

T2 - A novel bioactive ubiquinone from a marine bacterium Pseudoalteromonas sp. CGH2XX (Pseudoalteromonadaceae)

AU - Chen, Yu Hsin

AU - Lu, Mei Chin

AU - Chang, Yu Chia

AU - Hwang, Tsong Long

AU - Wang, Wei Hsien

AU - Weng, Ching Feng

AU - Kuo, Jimmy

AU - Sung, Ping Jyun

PY - 2012/3/28

Y1 - 2012/3/28

N2 - A novel ubiquinone derivative, pseudoalteromone A (1), possessing a 9C nor-monoterpenoid moiety was produced from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium is originally isolated from a cultured-type octocoral Lobophytum crassum. The structure of ubiquinone 1 was established by spectroscopic methods. Pseudoalteromone A (1) exhibited significant cytotoxicity toward the MOLT-4 (human acute lymphoblastic leukemia, IC 50 = 3.764 μg/mL) cells and displayed a significant inhibitory effect (inhibition rate 45.1%) on the release of elastase by human neutrophils at a concentration of 10 μg/mL.

AB - A novel ubiquinone derivative, pseudoalteromone A (1), possessing a 9C nor-monoterpenoid moiety was produced from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium is originally isolated from a cultured-type octocoral Lobophytum crassum. The structure of ubiquinone 1 was established by spectroscopic methods. Pseudoalteromone A (1) exhibited significant cytotoxicity toward the MOLT-4 (human acute lymphoblastic leukemia, IC 50 = 3.764 μg/mL) cells and displayed a significant inhibitory effect (inhibition rate 45.1%) on the release of elastase by human neutrophils at a concentration of 10 μg/mL.

KW - Cytotoxicity

KW - Elastase

KW - Lobophytum

KW - Pseudoalteromonas

KW - Pseudoalteromone

KW - Ubiquinone

UR - http://www.scopus.com/inward/record.url?scp=84862821833&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2012.01.104

DO - 10.1016/j.tetlet.2012.01.104

M3 - 文章

AN - SCOPUS:84862821833

SN - 0040-4039

VL - 53

SP - 1675

EP - 1677

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 13

ER -

Pseudoalteromone A: A novel bioactive ubiquinone from a marine bacterium Pseudoalteromonas sp. CGH2XX (Pseudoalteromonadaceae)

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this