Pubinernoid A and Apo-9′-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp

Hsin Huan Chang; Yu Chia Chang; Wu Fu Chen; Tsong Long Hwang; Lee Shing Fang; Zhi Hong Wen; Yu Hsin Chen; Yang Chang Wu; Ping Jyun Sung

doi:10.1177/1934578x1601100601

Pubinernoid A and Apo-9′-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp

Hsin Huan Chang, Yu Chia Chang, Wu Fu Chen, Tsong Long Hwang, Lee Shing Fang, Zhi Hong Wen, Yu Hsin Chen, Yang Chang Wu, Ping Jyun Sung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

The structures of pubinernoid A (1) and apo-9′-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9′-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC₅₀ value of 5.75 μM.

Original language	English
Pages (from-to)	707-708
Number of pages	2
Journal	Natural Product Communications
Volume	11
Issue number	6
DOIs	https://doi.org/10.1177/1934578x1601100601
State	Published - 06 2016

Keywords

Anti-inflammatory-activity
Apo-9′-fucoxanthinone
Elastase
Pinnigorgia
Pubinernoid A

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10.1177/1934578x1601100601

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title = "Pubinernoid A and Apo-9′-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp",

abstract = "The structures of pubinernoid A (1) and apo-9′-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9′-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 μM.",

keywords = "Anti-inflammatory-activity, Apo-9′-fucoxanthinone, Elastase, Pinnigorgia, Pubinernoid A",

author = "Chang, {Hsin Huan} and Chang, {Yu Chia} and Chen, {Wu Fu} and Hwang, {Tsong Long} and Fang, {Lee Shing} and Wen, {Zhi Hong} and Chen, {Yu Hsin} and Wu, {Yang Chang} and Sung, {Ping Jyun}",

year = "2016",

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doi = "10.1177/1934578x1601100601",

language = "英语",

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AU - Chang, Hsin Huan

AU - Chang, Yu Chia

AU - Chen, Wu Fu

AU - Hwang, Tsong Long

AU - Fang, Lee Shing

AU - Wen, Zhi Hong

AU - Chen, Yu Hsin

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

PY - 2016/6

Y1 - 2016/6

N2 - The structures of pubinernoid A (1) and apo-9′-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9′-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 μM.

AB - The structures of pubinernoid A (1) and apo-9′-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9′-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 μM.

KW - Anti-inflammatory-activity

KW - Apo-9′-fucoxanthinone

KW - Elastase

KW - Pinnigorgia

KW - Pubinernoid A

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DO - 10.1177/1934578x1601100601

M3 - 文章

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AN - SCOPUS:84989167935

SN - 1934-578X

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JO - Natural Product Communications

JF - Natural Product Communications

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ER -

Pubinernoid A and Apo-9′-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp

Abstract

Keywords

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