Pubinernoid A and Apo-9 '-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp.

Hsin-Huan Chang; Yu-Chia Chang; Wu-Fu Chen; Tsong-Long Hwang; Lee-Shing Fang; Zhi-Hong Wen; Yu-Hsin Chen; Yang-Chang Wu; Ping-Jyun Sung

Pubinernoid A and Apo-9 '-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp.

Hsin-Huan Chang, Yu-Chia Chang, Wu-Fu Chen, Tsong-Long Hwang, Lee-Shing Fang, Zhi-Hong Wen, Yu-Hsin Chen, Yang-Chang Wu, Ping-Jyun Sung

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

Abstract

The structures of pubinernoid A (1) and apo-9'-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9'-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 mu M.

Original language	American English
Pages (from-to)	707-708
Journal	Natural Product Communications
Volume	11
Issue number	6
State	Published - 2016

Keywords

9,11-SECOSTEROLS
A-C
Anti-inflammatory-activity
Apo-9 '-fucoxanthinone
Elastase
HUMAN NEUTROPHILS
INHIBITS SUPEROXIDE-PRODUCTION
Pinnigorgia
Pubinernoid A

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title = "Pubinernoid A and Apo-9 '-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp.",

abstract = "The structures of pubinernoid A (1) and apo-9'-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9'-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 mu M.",

keywords = "9,11-SECOSTEROLS, A-C, Anti-inflammatory-activity, Apo-9 '-fucoxanthinone, Elastase, HUMAN NEUTROPHILS, INHIBITS SUPEROXIDE-PRODUCTION, Pinnigorgia, Pubinernoid A",

author = "Hsin-Huan Chang and Yu-Chia Chang and Wu-Fu Chen and Tsong-Long Hwang and Lee-Shing Fang and Zhi-Hong Wen and Yu-Hsin Chen and Yang-Chang Wu and Ping-Jyun Sung",

year = "2016",

language = "American English",

volume = "11",

pages = "707--708",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "6",

}

TY - JOUR

T1 - Pubinernoid A and Apo-9 '-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp.

AU - Chang, Hsin-Huan

AU - Chang, Yu-Chia

AU - Chen, Wu-Fu

AU - Hwang, Tsong-Long

AU - Fang, Lee-Shing

AU - Wen, Zhi-Hong

AU - Chen, Yu-Hsin

AU - Wu, Yang-Chang

AU - Sung, Ping-Jyun

PY - 2016

Y1 - 2016

N2 - The structures of pubinernoid A (1) and apo-9'-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9'-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 mu M.

AB - The structures of pubinernoid A (1) and apo-9'-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9'-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 mu M.

KW - 9,11-SECOSTEROLS

KW - A-C

KW - Anti-inflammatory-activity

KW - Apo-9 '-fucoxanthinone

KW - Elastase

KW - HUMAN NEUTROPHILS

KW - INHIBITS SUPEROXIDE-PRODUCTION

KW - Pinnigorgia

KW - Pubinernoid A

M3 - Journal Article

SN - 1934-578X

VL - 11

SP - 707

EP - 708

JO - Natural Product Communications

JF - Natural Product Communications

IS - 6

ER -

Pubinernoid A and Apo-9 '-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp.

Abstract

Keywords

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