Pulmonary edema as a cause for fulminant death following microinjection of kainic acid into the rat medulla oblongata

Samuel H.H. Chan; Angela P.Y. Chong; B. T. Ong; O. K. Chong; H. C. Lim

doi:10.1016/0304-3940(85)90572-5

Pulmonary edema as a cause for fulminant death following microinjection of kainic acid into the rat medulla oblongata

Samuel H.H. Chan^*
, Angela P.Y. Chong
, B. T. Ong
, O. K. Chong
, H. C. Lim

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractility and heart rate before the animal succumbed to kainate neurotoxicity. It is suggested that the increased systemic hydrostatic pressure may retrogradely promote pulmonary hypertension that precipitates pulmonary edema.

Original language	English
Pages (from-to)	341-346
Number of pages	6
Journal	Neuroscience Letters
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(85)90572-5
State	Published - 18 12 1985
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

fulminant death
kainic acid
medulla oblongata rat
neurotoxicity
pulmonary edema

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10.1016/0304-3940(85)90572-5

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title = "Pulmonary edema as a cause for fulminant death following microinjection of kainic acid into the rat medulla oblongata",

abstract = "The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractility and heart rate before the animal succumbed to kainate neurotoxicity. It is suggested that the increased systemic hydrostatic pressure may retrogradely promote pulmonary hypertension that precipitates pulmonary edema.",

keywords = "fulminant death, kainic acid, medulla oblongata rat, neurotoxicity, pulmonary edema",

author = "Chan, \{Samuel H.H.\} and Chong, \{Angela P.Y.\} and Ong, \{B. T.\} and Chong, \{O. K.\} and Lim, \{H. C.\}",

year = "1985",

month = dec,

day = "18",

doi = "10.1016/0304-3940(85)90572-5",

language = "英语",

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journal = "Neuroscience Letters",

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T1 - Pulmonary edema as a cause for fulminant death following microinjection of kainic acid into the rat medulla oblongata

AU - Chan, Samuel H.H.

AU - Chong, Angela P.Y.

AU - Ong, B. T.

AU - Chong, O. K.

AU - Lim, H. C.

PY - 1985/12/18

Y1 - 1985/12/18

N2 - The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractility and heart rate before the animal succumbed to kainate neurotoxicity. It is suggested that the increased systemic hydrostatic pressure may retrogradely promote pulmonary hypertension that precipitates pulmonary edema.

AB - The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractility and heart rate before the animal succumbed to kainate neurotoxicity. It is suggested that the increased systemic hydrostatic pressure may retrogradely promote pulmonary hypertension that precipitates pulmonary edema.

KW - fulminant death

KW - kainic acid

KW - medulla oblongata rat

KW - neurotoxicity

KW - pulmonary edema

UR - https://www.scopus.com/pages/publications/0022399243

U2 - 10.1016/0304-3940(85)90572-5

DO - 10.1016/0304-3940(85)90572-5

M3 - 文章

C2 - 4094720

AN - SCOPUS:0022399243

SN - 0304-3940

VL - 62

SP - 341

EP - 346

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Pulmonary edema as a cause for fulminant death following microinjection of kainic acid into the rat medulla oblongata

Abstract

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Keywords

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