Pulse methylprednisolone therapy in the treatment of immune globulin-resistant Kawasaki disease: Case report and review of the literature

Jeng Juh Hung, Cheng Hsun Chiu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

A subgroup of patients with Kawasaki disease (KD) did not respond to intravenous immune globulin (IVIG) therapy. Corticosteroid therapy remains a controversial alternative in such cases. We report two young children with KD who failed to respond to three courses of IVIG therapy and subsequently received pulse methylprednisolone as an alternative. One had a satisfactory outcome but the other developed giant coronary aneurysms and had a myocardial infarction 2 months after onset of the illness. A review of relevant literature showed that the timing of initiation of pulse methylprednisolone therapy is importar. It is suggested that pulse methylprednisolone therapy should be considered if there is no response to two standard doses of IVIG treatment.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalAnnals of Tropical Paediatrics
Volume24
Issue number1
DOIs
StatePublished - 03 2004
Externally publishedYes

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