Pure XY gonadal dysgenesis and agenesis in monozygotic twins

Hui Yu Chen; Hong Yuan Huang; Ting Chang Chang; Chyong Huey Lai; Yung Kuei Soong

doi:10.1016/j.fertnstert.2005.09.054

Pure XY gonadal dysgenesis and agenesis in monozygotic twins

Hui Yu Chen, Hong Yuan Huang^*, Ting Chang Chang, Chyong Huey Lai, Yung Kuei Soong

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

Objective: To report a case of monozygotic twin sisters who had discordant gonadal dysgenesis although each had a normal 46,XY karyotype. Design: Case report. Setting: University tertiary hospital. Patient(s): Seventeen-year-old twin sisters, one with gonadal agenesis and the other with pure gonadal dysgenesis followed by dysgerminoma. Intervention(s): Blood samples were obtained for karyotyping and short tandem repeat polymorphism analysis (10 markers). Both patients underwent gonadectomy. Main Outcome Measure(s): Both sisters are well at time of report after gonadectomy for the sister with dysgerminoma and diagnostic laparoscope for the other. Result(s): Dysgerminoma and atrophic ovarian stromal and tubal structures. Conclusion(s): Monozygotic twins can have discordant gonadal dysgenesis even though they are identical genetically.

Original language	English
Pages (from-to)	1059.e9-1059.e11
Journal	Fertility and Sterility
Volume	85
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2005.09.054
State	Published - 04 2006
Externally published	Yes

Keywords

Amenorrhea
Monozygotic twin
Pure gonadal dysgenesis

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10.1016/j.fertnstert.2005.09.054

Cite this

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title = "Pure XY gonadal dysgenesis and agenesis in monozygotic twins",

abstract = "Objective: To report a case of monozygotic twin sisters who had discordant gonadal dysgenesis although each had a normal 46,XY karyotype. Design: Case report. Setting: University tertiary hospital. Patient(s): Seventeen-year-old twin sisters, one with gonadal agenesis and the other with pure gonadal dysgenesis followed by dysgerminoma. Intervention(s): Blood samples were obtained for karyotyping and short tandem repeat polymorphism analysis (10 markers). Both patients underwent gonadectomy. Main Outcome Measure(s): Both sisters are well at time of report after gonadectomy for the sister with dysgerminoma and diagnostic laparoscope for the other. Result(s): Dysgerminoma and atrophic ovarian stromal and tubal structures. Conclusion(s): Monozygotic twins can have discordant gonadal dysgenesis even though they are identical genetically.",

keywords = "Amenorrhea, Monozygotic twin, Pure gonadal dysgenesis",

author = "Chen, {Hui Yu} and Huang, {Hong Yuan} and Chang, {Ting Chang} and Lai, {Chyong Huey} and Soong, {Yung Kuei}",

year = "2006",

month = apr,

doi = "10.1016/j.fertnstert.2005.09.054",

language = "英语",

volume = "85",

pages = "1059.e9--1059.e11",

journal = "Fertility and Sterility",

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number = "4",

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T1 - Pure XY gonadal dysgenesis and agenesis in monozygotic twins

AU - Chen, Hui Yu

AU - Huang, Hong Yuan

AU - Chang, Ting Chang

AU - Lai, Chyong Huey

AU - Soong, Yung Kuei

PY - 2006/4

Y1 - 2006/4

N2 - Objective: To report a case of monozygotic twin sisters who had discordant gonadal dysgenesis although each had a normal 46,XY karyotype. Design: Case report. Setting: University tertiary hospital. Patient(s): Seventeen-year-old twin sisters, one with gonadal agenesis and the other with pure gonadal dysgenesis followed by dysgerminoma. Intervention(s): Blood samples were obtained for karyotyping and short tandem repeat polymorphism analysis (10 markers). Both patients underwent gonadectomy. Main Outcome Measure(s): Both sisters are well at time of report after gonadectomy for the sister with dysgerminoma and diagnostic laparoscope for the other. Result(s): Dysgerminoma and atrophic ovarian stromal and tubal structures. Conclusion(s): Monozygotic twins can have discordant gonadal dysgenesis even though they are identical genetically.

AB - Objective: To report a case of monozygotic twin sisters who had discordant gonadal dysgenesis although each had a normal 46,XY karyotype. Design: Case report. Setting: University tertiary hospital. Patient(s): Seventeen-year-old twin sisters, one with gonadal agenesis and the other with pure gonadal dysgenesis followed by dysgerminoma. Intervention(s): Blood samples were obtained for karyotyping and short tandem repeat polymorphism analysis (10 markers). Both patients underwent gonadectomy. Main Outcome Measure(s): Both sisters are well at time of report after gonadectomy for the sister with dysgerminoma and diagnostic laparoscope for the other. Result(s): Dysgerminoma and atrophic ovarian stromal and tubal structures. Conclusion(s): Monozygotic twins can have discordant gonadal dysgenesis even though they are identical genetically.

KW - Amenorrhea

KW - Monozygotic twin

KW - Pure gonadal dysgenesis

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IS - 4

ER -

Pure XY gonadal dysgenesis and agenesis in monozygotic twins

Abstract

Keywords

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