Quantification of Captopril in Urine Through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using 4-Mercaptobenzoic Acid-Capped Gold Nanoparticles as an Internal Standard

Wen Tsen Chen; Cheng Kang Chiang; Yang Wei Lin; Huan Tsung Chang

doi:10.1016/j.jasms.2010.01.023

Quantification of Captopril in Urine Through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using 4-Mercaptobenzoic Acid-Capped Gold Nanoparticles as an Internal Standard

Wen Tsen Chen
, Cheng Kang Chiang
, Yang Wei Lin
, Huan Tsung Chang^*

^*Corresponding author for this work

National Taiwan University

Research output: Contribution to journal › Journal Article › peer-review

45 Scopus citations

Abstract

We have developed a new internal standard method for the determination of the concentration of captopril (CAP) through surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using gold nanoparticles (Au NPs). This approach provided linearity for CAP over the concentration range 2.525 M (R² = 0.987), with a limit of detection (signal-to-noise ratio = 3) of 1.0 M. The spot-to-spot variations in the concentration of CAP through SALDI-MS analyses performed in the absence and presence of the internal standard were 26% and 9%, respectively (15 measurements). This approach provides simplicity, accuracy, precision, and great reproducibility to the determination of the levels of CAP in human urine samples.

Original language	English
Pages (from-to)	864-867
Number of pages	4
Journal	Journal of the American Society for Mass Spectrometry
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.jasms.2010.01.023
State	Published - 05 2010
Externally published	Yes

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10.1016/j.jasms.2010.01.023

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@article{55944ec55fd04f768c1504d2bdbaf8b6,

title = "Quantification of Captopril in Urine Through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using 4-Mercaptobenzoic Acid-Capped Gold Nanoparticles as an Internal Standard",

abstract = "We have developed a new internal standard method for the determination of the concentration of captopril (CAP) through surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using gold nanoparticles (Au NPs). This approach provided linearity for CAP over the concentration range 2.525 M (R2 = 0.987), with a limit of detection (signal-to-noise ratio = 3) of 1.0 M. The spot-to-spot variations in the concentration of CAP through SALDI-MS analyses performed in the absence and presence of the internal standard were 26\% and 9\%, respectively (15 measurements). This approach provides simplicity, accuracy, precision, and great reproducibility to the determination of the levels of CAP in human urine samples.",

author = "Chen, \{Wen Tsen\} and Chiang, \{Cheng Kang\} and Lin, \{Yang Wei\} and Chang, \{Huan Tsung\}",

year = "2010",

month = may,

doi = "10.1016/j.jasms.2010.01.023",

language = "英语",

volume = "21",

pages = "864--867",

journal = "Journal of the American Society for Mass Spectrometry",

issn = "1044-0305",

publisher = "American Chemical Society",

number = "5",

}

Quantification of Captopril in Urine Through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using 4-Mercaptobenzoic Acid-Capped Gold Nanoparticles as an Internal Standard. / Chen, Wen Tsen; Chiang, Cheng Kang; Lin, Yang Wei et al.
In: Journal of the American Society for Mass Spectrometry, Vol. 21, No. 5, 05.2010, p. 864-867.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Quantification of Captopril in Urine Through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using 4-Mercaptobenzoic Acid-Capped Gold Nanoparticles as an Internal Standard

AU - Chen, Wen Tsen

AU - Chiang, Cheng Kang

AU - Lin, Yang Wei

AU - Chang, Huan Tsung

PY - 2010/5

Y1 - 2010/5

N2 - We have developed a new internal standard method for the determination of the concentration of captopril (CAP) through surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using gold nanoparticles (Au NPs). This approach provided linearity for CAP over the concentration range 2.525 M (R2 = 0.987), with a limit of detection (signal-to-noise ratio = 3) of 1.0 M. The spot-to-spot variations in the concentration of CAP through SALDI-MS analyses performed in the absence and presence of the internal standard were 26% and 9%, respectively (15 measurements). This approach provides simplicity, accuracy, precision, and great reproducibility to the determination of the levels of CAP in human urine samples.

AB - We have developed a new internal standard method for the determination of the concentration of captopril (CAP) through surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using gold nanoparticles (Au NPs). This approach provided linearity for CAP over the concentration range 2.525 M (R2 = 0.987), with a limit of detection (signal-to-noise ratio = 3) of 1.0 M. The spot-to-spot variations in the concentration of CAP through SALDI-MS analyses performed in the absence and presence of the internal standard were 26% and 9%, respectively (15 measurements). This approach provides simplicity, accuracy, precision, and great reproducibility to the determination of the levels of CAP in human urine samples.

UR - https://www.scopus.com/pages/publications/77951203738

U2 - 10.1016/j.jasms.2010.01.023

DO - 10.1016/j.jasms.2010.01.023

M3 - 文章

C2 - 20171117

AN - SCOPUS:77951203738

SN - 1044-0305

VL - 21

SP - 864

EP - 867

JO - Journal of the American Society for Mass Spectrometry

JF - Journal of the American Society for Mass Spectrometry

IS - 5

ER -

Quantification of Captopril in Urine Through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using 4-Mercaptobenzoic Acid-Capped Gold Nanoparticles as an Internal Standard

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