Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

Yao Kuang Wu; Kuei Tien Chen; Yung Bin Kuo; Ya Shu Huang; Err Cheng Chan

doi:10.1016/j.canlet.2008.08.023

Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

Yao Kuang Wu, Kuei Tien Chen, Yung Bin Kuo, Ya Shu Huang, Err Cheng Chan^*

^*Corresponding author for this work

Department of Medical Biotechnology and Laboratory Science

Research output: Contribution to journal › Journal Article › peer-review

31 Scopus citations

Abstract

In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.

Original language	English
Pages (from-to)	331-335
Number of pages	5
Journal	Cancer Letters
Volume	273
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.08.023
State	Published - 18 01 2009

Keywords

Lung cancer
Pleural effusion
Prognosis
Survival rate
Survivin expression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2008.08.023

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title = "Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer",

abstract = "In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.",

keywords = "Lung cancer, Pleural effusion, Prognosis, Survival rate, Survivin expression",

author = "Wu, {Yao Kuang} and Chen, {Kuei Tien} and Kuo, {Yung Bin} and Huang, {Ya Shu} and Chan, {Err Cheng}",

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TY - JOUR

T1 - Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

AU - Wu, Yao Kuang

AU - Chen, Kuei Tien

AU - Kuo, Yung Bin

AU - Huang, Ya Shu

AU - Chan, Err Cheng

PY - 2009/1/18

Y1 - 2009/1/18

N2 - In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.

AB - In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.

KW - Lung cancer

KW - Pleural effusion

KW - Prognosis

KW - Survival rate

KW - Survivin expression

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DO - 10.1016/j.canlet.2008.08.023

M3 - 文章

C2 - 18824294

AN - SCOPUS:57449085352

SN - 0304-3835

VL - 273

SP - 331

EP - 335

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

Abstract

Keywords

UN SDGs

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