Randainins A-D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis

Ho Hsi Cheng, Yuan Bin Cheng, Tsong Long Hwang, Yao Haur Kuo, Chung Hsiung Chen, Ya Ching Shen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations

Abstract

Four new compounds, randainins A-D (1-4), were isolated from the leaves and twigs of Callicarpa randaiensis, which is an endemic species in Taiwan. Compounds 1 and 2 are diterpenoids with an unusual trans-7/5 ring system, whereas compounds 3 and 4 are diterpenoids possessing a trans-5/7 ring scaffold. The structures of the new compounds were established based on NMR and MS data analyses. Anti-inflammatory activities and cytotoxicity were tested and evaluated for these compounds. Compound 4 exhibited moderate inhibition of superoxide-anion generation with an IC50 value of 21.5 ± 2.5 μM. (Figure Presented).

Original languageEnglish
Pages (from-to)1823-1828
Number of pages6
JournalJournal of Natural Products
Volume78
Issue number8
DOIs
StatePublished - 28 08 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society and American Society of Pharmacognosy.

Fingerprint

Dive into the research topics of 'Randainins A-D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis'. Together they form a unique fingerprint.

Cite this