Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

Feng Wei Lin; Pin Yuan Chen; Kuo Chen Wei; Chiung Yin Huang; Chih Kuang Wang; Hung Wei Yang

doi:10.7150/thno.19856

Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

Feng Wei Lin, Pin Yuan Chen, Kuo Chen Wei, Chiung Yin Huang, Chih Kuang Wang, Hung Wei Yang^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.

Original language	English
Pages (from-to)	2524-2536
Number of pages	13
Journal	Theranostics
Volume	7
Issue number	9
DOIs	https://doi.org/10.7150/thno.19856
State	Published - 2017

Bibliographical note

Publisher Copyright:
© Ivyspring International Publisher.

Keywords

Brain tumor
MRI traceability
Sustained drug release
Thermosensitivity hydrogels
Tumor recurrence

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10.7150/thno.19856

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title = "Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor",

abstract = "Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.",

keywords = "Brain tumor, MRI traceability, Sustained drug release, Thermosensitivity hydrogels, Tumor recurrence",

author = "Lin, {Feng Wei} and Chen, {Pin Yuan} and Wei, {Kuo Chen} and Huang, {Chiung Yin} and Wang, {Chih Kuang} and Yang, {Hung Wei}",

note = "Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",

year = "2017",

doi = "10.7150/thno.19856",

language = "英语",

volume = "7",

pages = "2524--2536",

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TY - JOUR

T1 - Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

AU - Lin, Feng Wei

AU - Chen, Pin Yuan

AU - Wei, Kuo Chen

AU - Huang, Chiung Yin

AU - Wang, Chih Kuang

AU - Yang, Hung Wei

N1 - Publisher Copyright: © Ivyspring International Publisher.

PY - 2017

Y1 - 2017

N2 - Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.

AB - Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.

KW - Brain tumor

KW - MRI traceability

KW - Sustained drug release

KW - Thermosensitivity hydrogels

KW - Tumor recurrence

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U2 - 10.7150/thno.19856

DO - 10.7150/thno.19856

M3 - 文章

C2 - 28744332

AN - SCOPUS:85021229210

SN - 1838-7640

VL - 7

SP - 2524

EP - 2536

JO - Theranostics

JF - Theranostics

IS - 9

ER -

Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

Abstract

Bibliographical note

Keywords

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