Rapid on-chip heterogeneous bone-cell patterning via the enhanced dielectrophoresis trap for tissue engineering application

Chen Ta Ho, Ruei Zeng Lin, Hwan You Chang, Cheng Hsien Liu

Research output: Contribution to conferenceConference Paperpeer-review

Abstract

A bone-mimetic cell-patterning technique for on-chip reconstructing heterogeneous osteocytes and hydroxyapatite particles via the design of enhanced field-induced dielectrophoresis (DEP) trap is demonstrated and reported in this paper. We mimic the morphology of the Haversian canal system of bone tissue to design the concentricradial-tip-array electrodes for DEP operation. Well-defined and enhanced spatial electric field gradients are created for the in-parallel manipulation of massive individual cells and particles to from the biomimic pattern via vertical/horizontal DEP operation alternatively. Experiment results show that the osteocytes are positioned to from the shape of multiple concentric rings interlaced with pearl chain array of hydroxyapatites, which form bone-mimetic pattern. Good cell viability after cell-patterning is observed.

Original languageEnglish
Pages1537-1539
Number of pages3
StatePublished - 2006
Externally publishedYes
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: 05 11 200609 11 2006

Conference

Conference10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
Country/TerritoryJapan
CityTokyo
Period05/11/0609/11/06

Keywords

  • Bone
  • Cell patterning
  • Dielectrophoresis
  • Tissue engineering

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