Abstract
A bone-mimetic cell-patterning technique for on-chip reconstructing heterogeneous osteocytes and hydroxyapatite particles via the design of enhanced field-induced dielectrophoresis (DEP) trap is demonstrated and reported in this paper. We mimic the morphology of the Haversian canal system of bone tissue to design the concentricradial-tip-array electrodes for DEP operation. Well-defined and enhanced spatial electric field gradients are created for the in-parallel manipulation of massive individual cells and particles to from the biomimic pattern via vertical/horizontal DEP operation alternatively. Experiment results show that the osteocytes are positioned to from the shape of multiple concentric rings interlaced with pearl chain array of hydroxyapatites, which form bone-mimetic pattern. Good cell viability after cell-patterning is observed.
Original language | English |
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Pages | 1537-1539 |
Number of pages | 3 |
State | Published - 2006 |
Externally published | Yes |
Event | 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 05 11 2006 → 09 11 2006 |
Conference
Conference | 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 |
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Country/Territory | Japan |
City | Tokyo |
Period | 05/11/06 → 09/11/06 |
Keywords
- Bone
- Cell patterning
- Dielectrophoresis
- Tissue engineering